Record in detail


General Info

  • lamp_id:L01A000221
  • Name:PR39_PIG
  • FullName:Antibacterial protein PR-39
  • Source:Sus scrofa
  • Mass:4720.6 Da
  • Sequence Length:39 aa
  • Isoelectric Point:13.1
  • Activity:Antibacterial,Anticancer
  • Sequence
        RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP
  • Function:Exerts a potent antimicrobial activity against both E.coli and B.megaterium.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000221    From 1 To 39 E-value: 0.00000000004 Score: 58.5
        RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP
  • 2. L11A012373    From 1 To 15 E-value: 0.93 Score: 24.3
        RRRPRPPYLNRPRPP

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli K12 D21  MIC:  1.42 μg/ml  (0.300809 μM)  
  •   2  Target:  E. coli Bd2221175  MIC:  1.42 μg/ml  (0.300809 μM)  
  •   3  Target:  S. typhimurium LT2  MIC:  4.72 μg/ml  (0.999873 μM)  
  •   4  Target:  P. vulgaris Pvll  MIC:  1416.18 μg/ml  (300 μM)  
  •   5  Target:  Ps.aeruginosa OT97  MIC:  944.12 μg/ml  (200 μM)  
  •   6  Target:  A. calcoaceticus Acl 1  MIC:  14.16 μg/ml  (2.99962 μM)  
  •   7  Target:  B. megaterium  MIC:  1.42 μg/ml  (0.300809 μM)  
  •   8  Target:  B. subtilis  MIC:  70.81 μg/ml  (15.0002 μM)  
  •   9  Target:  S.aureus  MIC:  944.12 μg/ml  (200 μM)  
  •   10  Target:  Streptococcus. pyogenes  MIC:  9.44 μg/ml  (1.99975 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Boman H.G.,Carlquist M.,Bergman T.,Lee J.-Y.,Agerberth B.,
  •   Title:Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides.
  •   Journal:Eur. J. Biochem., 1991, 202, 849-854  [MEDLINE:92111534]
  •   [2]  Zanetti M.,Storici P.,
  •   Title:A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39.
  •   Journal:Biochem. Biophys. Res. Commun., 1993, 196, 1058-1065  [MEDLINE:94071853]
  •   [3]  Blecha F.,Chengappa M.M.,Ross C.R.,Shi J.,
  •   Title:Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine.
  •   Journal:J. Leukoc. Biol., 1994, 56, 807-811  [MEDLINE:95088504]
  •   [4]  Andersson L.,Johansson M.,Chowdhary B.P.,Magnusson K.P.,Gudmundsson G.H.,
  •   Title:Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 7085-7089  [MEDLINE:95350216]
  •   [5]  Lehrer R.I.,Ganz T.,Zhao C.,
  •   Title:Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39.
  •   Journal:FEBS Lett., 1995, 376, 130-134  [MEDLINE:96105365]

Comments

  •   Comments

    •     No comments found on LAMP database



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