Record in detail


General Info

  • lamp_id:L01A000226
  • Name:CIRB_CHAPA
  • FullName:Circulin-B
  • Source:Chassalia parviflora
  • Mass:3307.9 Da
  • Sequence Length:31 aa
  • Isoelectric Point:8.11
  • Activity:Antibacterial
  • Sequence
        GVIPCGESCVFIPCISTLLGCSCKNKVCYRN
  • Function:Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against both Gram-positive and Gram-negative bacteria.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A05610|    From 61 To 91 E-value: 0.0000000000003 Score: 65.5
        GVIPCGESCVFIPCISSVLGCSCKNKVCYRN
  • 2. L01A000226    From 1 To 31 E-value: 0.000000000001 Score: 63.5
        GVIPCGESCVFIPCISTLLGCSCKNKVCYRN
  • 3. L12A04244|    From 1 To 31 E-value: 0.000000000005 Score: 61.6
        GVIPCGESCVFIPCISTVIGCSCKNKVCYRN
  • 4. L12A04827|    From 1 To 29 E-value: 0.00000000001 Score: 60.1
        IPCGESCVFIPCISTVIGCSCKNKVCYRN
  • 5. L13A023363    From 1 To 31 E-value: 0.00000000001 Score: 60.1
        GVIPCGESCVFIPCISSVLGCSCKNKVCYRD

Structure

  •   Domains
  •   1  Name:Cyclotide    Interpro Link:IPR005535
  •   2  Name:Cyclotide_bracelet_CS    Interpro Link:IPR012323
  •   3  Name:Cyclotide_subgr    Interpro Link:IPR017307
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  1.36 μg/ml  (0.411137 μM)  
  •   2  Target:  P. aeruginosa  MIC:  84.35 μg/ml  (25.4996 μM)  
  •   3  Target:  Pr. Vulgaris  MIC:  22.49 μg/ml  (6.79888 μM)  
  •   4  Target:  K. oxytoca  MIC:  27.12 μg/ml  (8.19856 μM)  
  •   5  Target:  S. aureus  MIC:  44.66 μg/ml  (13.501 μM)  
  •   6  Target:  C. kefyr  MIC:  95.93 μg/ml  (29.0003 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Suzuki T.,Suketa Y.,Hayashi K.,
  •   Title:Chemical structure of circulin B.
  •   Journal:Experientia, 1968, 24, 656-657  [MEDLINE:69089464]
  •   [2]  Kashman Y.,Parson I.C.,Henderson L.E.,Sowder R.C. II,Gustafson K.R.,
  •   Title:Circulins A and B: novel HIV-inhibitor macrocyclic peptide from tropical tree Chassalia parvifolia.
  •   Journal:J. Am. Chem. Soc., 1994, 116, 9337-9338  [DOI:10.1021/ja00099a064]
  •   [3]  Pannell L.K.,Gustafson K.R.,Derua R.,
  •   Title:Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides.
  •   Journal:Biochem. Biophys. Res. Commun., 1996, 228, 632-638  [MEDLINE:97079229]
  •   [4]  Chiu K.-W.,Yang J.-L.,Lu Y.-A.,Tam J.P.,
  •   Title:An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1999, 96, 8913-8918  [MEDLINE:99362685]
  •   [5]  Craik D.J.,Gustafson K.R.,Daly N.L.,Koltay A.,
  •   Title:Structure of circulin B and implications for antimicrobial activity of the cyclotides.
  •   Journal:Int. J. Pept. Protein Res., 2005, 11, 99-106  [:]

Comments

  •   Comments

    •     No comments found on LAMP database



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