Record in detail


General Info

  • lamp_id:L01A000250
  • Name:AUR12_LITRA
  • FullName:Aurein-1.2
  • Source:Litoria raniformis
  • Mass:1480.7 Da
  • Sequence Length:13 aa
  • Isoelectric Point:6.51
  • Activity:Antibacterial, ,Anticancer,Anticancer
  • Sequence
        GLFDIIKKIAESF
  • Function:Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A03275|    From 1 To 13 E-value: 0.039 Score: 27.7
        GLFDIIKKIAESF
  • 2. L01A000250    From 1 To 13 E-value: 0.039 Score: 27.7
        GLFDIIKKIAESF
  • 3. L13A024169    From 15 To 27 E-value: 0.047 Score: 27.3
        GLFDIIKKIAESF
  • 4. L13A013437    From 1 To 13 E-value: 0.048 Score: 27.3
        GLFDIIKKIAESF
  • 5. L13A027567    From 1 To 13 E-value: 0.079 Score: 26.6
        GLFDIIKKIAESW

Structure

  •   Domains
  •   1  Name:Aurein_antimicrobial_peptide    Interpro Link:IPR013157
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  [ Refer PubMed 10951191 : - B.cereus  MIC:  100 μg/ml  (67.5356 μM)  
  •   2  Target:  L.lactis  MIC:  12 μg/ml  (8.10428 μM)  
  •   3  Target:  L.innocua  MIC:  100 μg/ml  (67.5356 μM)  
  •   4  Target:  M.luteus  MIC:  100 μg/ml  (67.5356 μM)  
  •   5  Target:  P.multocida  MIC:  100 μg/ml  (67.5356 μM)  
  •   6  Target:  S.aureus  MIC:  50 μg/ml  (33.7678 μM)  
  •   7  Target:  S.epidermidis  MIC:  50 μg/ml  (33.7678 μM)  
  •   8  Target:  S.uberis  MIC:  50 μg/ml  (33.7678 μM)  
  •   9  Target:  ] [ Refer 15572363 :- E.coli  MIC:  111.05 μg/ml  (74.9983 μM)  
  •   10  Target:  S. aureus  MIC:  50.0921 μg/ml  (33.83 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
  •   Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
  •   Journal:Eur. J. Biochem., 2000, 267, 5330-5341  [MEDLINE:20408845]

Comments

  •   Comments

    •     No comments found on LAMP database



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