Record in detail

General Info

lamp_id:L01A000254
Name:AUR26_LITRA
FullName:Aurein-2.6
Source:Litoria raniformis
Mass:1630 Da
Sequence Length:16 aa
Isoelectric Point:9.53
Activity:Antibacterial, ,Anticancer,Anticancer
Sequence
GLFDIAKKVIGVIGSL
Function:Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, S.aureus, and S.epidermidis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Cross-linking
1 Database:APD 19
2 Database:CAMP CAMPSQ232
3 Database:DBAASP 780
4 Database:dbAMP dbAMP_03273
5 Database:DRAMP DRAMP01613
6 Database:SATPdb satpdb21733
7 Database:Uniprot P82393

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000254 From 1 To 16 E-value: 0.003 Score: 31.6
GLFDIAKKVIGVIGSL
2. L13A021354 From 1 To 15 E-value: 0.009 Score: 30
GLFDIAKKVIGVIGS
3. L12A06194| From 50 To 65 E-value: 0.014 Score: 29.3
GLFDIVKKVVGAIGSL
4. L12A06193| From 50 To 65 E-value: 0.034 Score: 28.1
GLFDIVKKVVGALGSL
5. L01A000252 From 1 To 16 E-value: 0.041 Score: 27.7
GLFDIVKKVVGAIGSL

Structure

Domains
1 Name:Aurein_antimicrobial_peptide Interpro Link:IPR013157

Structures

Activity

Antibacterial Activities
1 Target: B. cereus MIC: 100 μg/ml (61.3497 μM)
2 Target: L. lactis MIC: 6 μg/ml (3.68098 μM)
3 Target: L. innocua MIC: 100 μg/ml (61.3497 μM)
4 Target: M. luteus MIC: 25 μg/ml (15.3374 μM)
5 Target: S. aureus MIC: 50 μg/ml (30.6748 μM)
6 Target: S. epidermidis MIC: 50 μg/ml (30.6748 μM)

Toxicity

Toxicity

Reference

Reference
[1] Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
Journal:Eur. J. Biochem., 2000, 267, 5330-5341 [MEDLINE:20408845]

Comments

Comments