Record in detail

General Info

lamp_id:L01A000255
Name:AUR33_LITRA
FullName:Aurein-3.3
Source:Litoria raniformis
Mass:1797.1 Da
Sequence Length:17 aa
Isoelectric Point:9.53
Activity:Antibacterial, ,Anticancer,Anticancer
Sequence
GLFDIVKKIAGHIVSSI
Function:Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Cross-linking
1 Database:APD 22
2 Database:CAMP CAMPSQ233
3 Database:DBAASP 781
4 Database:dbAMP dbAMP_03288
5 Database:DRAMP DRAMP01618
6 Database:SATPdb satpdb13076
7 Database:Uniprot P82396

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000255 From 1 To 17 E-value: 0.0005 Score: 34.3
GLFDIVKKIAGHIVSSI
2. L01A000622 From 1 To 17 E-value: 0.001 Score: 33.1
GLFDIVKKIAGHIASSI
3. L12A06191| From 50 To 66 E-value: 0.002 Score: 32.3
GLFDIVKKIAGHIAGSI
4. L01A000620 From 1 To 17 E-value: 0.004 Score: 31.2
GLFDIVKKIAGHIAGSI
5. L13A014448 From 1 To 15 E-value: 0.007 Score: 30.4
FDIVKKIAGHIVSSI

Structure

Domains
1 Name:Aurein_antimicrobial_peptide Interpro Link:IPR013157

Structures

Activity

Antibacterial Activities
1 Target: Leuconostoc lactis MIC: 12 μg/ml (6.67742 μM)
2 Target: Micrococcus luteus MIC: 100 μg/ml (55.6452 μM)
3 Target: Pasteurella multocida MIC: 100 μg/ml (55.6452 μM)
4 Target: Staphylococcus aureus MIC: 100 μg/ml (55.6452 μM)
5 Target: Staphylococcus epidermidis MIC: 50 μg/ml (27.8226 μM)
6 Target: Streptococcus uberis MIC: 25 μg/ml (13.9113 μM)

Toxicity

Toxicity

Reference

Reference
[1] Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
Journal:Eur. J. Biochem., 2000, 267, 5330-5341 [MEDLINE:20408845]

Comments

Comments