Record in detail


General Info

  • lamp_id:L01A000255
  • Name:AUR33_LITRA
  • FullName:Aurein-3.3
  • Source:Litoria raniformis
  • Mass:1797.1 Da
  • Sequence Length:17 aa
  • Isoelectric Point:9.53
  • Activity:Antibacterial, ,Anticancer,Anticancer
  • Sequence
        GLFDIVKKIAGHIVSSI
  • Function:Antimicrobial activity against L.lactis, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000255    From 1 To 17 E-value: 0.0005 Score: 34.3
        GLFDIVKKIAGHIVSSI
  • 2. L01A000622    From 1 To 17 E-value: 0.001 Score: 33.1
        GLFDIVKKIAGHIASSI
  • 3. L12A06191|    From 50 To 66 E-value: 0.002 Score: 32.3
        GLFDIVKKIAGHIAGSI
  • 4. L01A000620    From 1 To 17 E-value: 0.004 Score: 31.2
        GLFDIVKKIAGHIAGSI
  • 5. L13A014448    From 1 To 15 E-value: 0.007 Score: 30.4
        FDIVKKIAGHIVSSI

Structure

  •   Domains
  •   1  Name:Aurein_antimicrobial_peptide    Interpro Link:IPR013157
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Leuconostoc lactis  MIC:  12 μg/ml  (6.67742 μM)  
  •   2  Target:  Micrococcus luteus  MIC:  100 μg/ml  (55.6452 μM)  
  •   3  Target:  Pasteurella multocida  MIC:  100 μg/ml  (55.6452 μM)  
  •   4  Target:  Staphylococcus aureus  MIC:  100 μg/ml  (55.6452 μM)  
  •   5  Target:  Staphylococcus epidermidis  MIC:  50 μg/ml  (27.8226 μM)  
  •   6  Target:  Streptococcus uberis  MIC:  25 μg/ml  (13.9113 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
  •   Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
  •   Journal:Eur. J. Biochem., 2000, 267, 5330-5341  [MEDLINE:20408845]

Comments

  •   Comments

  •     No comments found on LAMP database



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