Record in detail
General Info
- lamp_id:L01A000258
- Name:DEF1_PEA
- FullName:Defensin-1
- Source:Pisum sativum
- Mass:5208.8 Da
- Sequence Length:46 aa
- Isoelectric Point:7.71
- Activity:Antifungal
- Sequence
KTCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHNWKCFCTQNC - Function:Possesses antifungal activity sensitive to inorganic cations.
Cross-Linking
- Cross-linking
- 1 Database:APD 483
- 2 Database:CAMP CAMPSQ236
- 3 Database:DBAASP 782
- 4 Database:dbAMP dbAMP_05372
- 5 Database:DRAMP DRAMP00436
- 6 Database:SATPdb satpdb24432
- 7 Database:Uniprot P81929
- 8 Database:AMD PDEF3_PISSA
- 9 Database:PHY PHYT00009
- 10 Database:RAP RAPD0102
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000258 From 1 To 46 E-value: 2e-22 Score: 95.9
KTCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHNWKCFCTQNC - 2. L03A000110 From 30 To 74 E-value: 4e-22 Score: 94.7
TCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHDWKCFCTQNC - 3. L01A002975 From 2 To 46 E-value: 2e-21 Score: 92.8
TCEHLADTYRGVCFTNASCDDHCKNKAHLISGTCHDWKCFCTQNC - 4. L03A000109 From 29 To 75 E-value: 0.00000000000006 Score: 67.8
KTCENLVDTYRGPCFTTGSCDDHCKNKEHLLSGRCRDDVRCWCTRNC - 5. L07APD0170 From 1 To 47 E-value: 0.00000000000008 Score: 67.4
KTCENLADTYRGPCFTTGSCDDHCKNKEHLLSGRCRDDVRCWCTRNC
Structure
- Structures
- 1
PDB:1JKZ
Method:NMR
Chains:A=1-46 - 2
PDB:2IIW
Method:Model
Chains:A=1-46 - 3
PDB:2IJ1
Method:Model
Chains:A=1-46 - 4
PDB:2IJT
Method:Model
Chains:A=1-46 - 5
PDB:2IJU
Method:Model
Chains:A=1-46 - 6
PDB:2IJV
Method:Model
Chains:A=1-46 - 7
PDB:2IJW
Method:Model
Chains:A=1-46 - 8
PDB:2IKL
Method:Model
Chains:A=1-46 - 9
PDB:2IKM
Method:Model
Chains:A=1-46 - 10
PDB:2IKN
Method:Model
Chains:A=1-46 - 11
PDB:2IKP
Method:Model
Chains:A=1-46 - 12
PDB:2IKR
Method:Model
Chains:A=1-46 - 13
PDB:2IKT
Method:Model
Chains:A=1-46 - 14
PDB:2IKV
Method:Model
Chains:A=1-46 - 15
PDB:2IKW
Method:Model
Chains:A=1-46 - 16
PDB:2IKX
Method:Model
Chains:A=1-46 - 17
PDB:2IKY
Method:Model
Chains:A=1-46 - 18
PDB:2IKZ
Method:Model
Chains:A=1-46 - 19
PDB:2IL0
Method:Model
Chains:A=1-46 - 20
PDB:2ILC
Method:Model
Chains:A=1-46 - 21
PDB:2ILD
Method:Model
Chains:A=1-46 - 22
PDB:2ILE
Method:Model
Chains:A=1-46 - 23
PDB:2ILF
Method:Model
Chains:A=1-46 - 24
PDB:2ILG
Method:Model
Chains:A=1-46 - 25
PDB:2ILH
Method:Model
Chains:A=1-46 - 26
PDB:2ILJ
Method:Model
Chains:A=1-46
Activity
- Antibacterial Activities
- 1 Target: Aspergillus niger MIC: 12.1 μg/ml (2.32299 μM)
- 2 Target: Fusarium moniliforme MIC: 21.7 μg/ml (4.16603 μM)
- 3 Target: Fusarium oxysporum MIC: 100 μg/ml (19.1983 μM)
- 4 Target: Fusarium solani MIC: 12.1 μg/ml (2.32299 μM)
- 5 Target: Neurospora crassa MIC: 0.04 μg/ml (0.00767931 μM)
- 6 Target: Saccharomyces cerevisae MIC: 100 μg/ml (19.1983 μM)
- 7 Target: Trichophyton mentagrophytes MIC: 100 μg/ml (19.1983 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Kurtenbach E.,Zingali R.B.,Cabral K.M.,Almeida M.S.,
- Title:Characterization of two novel defense peptides from pea (Pisum sativum) seeds.
- Journal:Arch. Biochem. Biophys., 2000, 378, 278-286 [MEDLINE:20318322]
- [2] Almeida F.C.,Valente A.P.,de Medeiros L.N.,Cabral K.S.,Almeida M.S.,
- Title:cDNA cloning and heterologous expression of functional cysteine-rich antifungal protein Psd1 in the yeast Pichia pastoris.
- Journal:Arch. Biochem. Biophys., 2001, 395, 199-207 [MEDLINE:21554729]
- [3] Valente A.P.,Almeida F.C.,Kurtenbach E.,Cabral K.M.,Almeida M.S.,
- Title:Solution structure of Pisum sativum defensin 1 by high resolution NMR: plant defensins, identical backbone with different mechanisms of action.
- Journal:J. Mol. Biol., 2002, 315, 749-757 [MEDLINE:21671496]
Comments
- Comments
No comments found on LAMP database