Record in detail


General Info

  • lamp_id:L01A000260
  • Name:DCD_HUMAN
  • FullName:Dermcidin
  • Source:Homo sapiens
  • Mass:4705.3 Da
  • Sequence Length:47 aa
  • Isoelectric Point:4.89
  • Activity:Antibacterial, Antifungal
  • Sequence
        SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV
  • Function:DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000260    From 1 To 47 E-value: 7e-19 Score: 84.3
        SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV
  • 2. L07APD0043    From 1 To 47 E-value: 7e-19 Score: 84.3
        SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV
  • 3. L11A003198    From 1 To 47 E-value: 3e-18 Score: 82.4
        SSLLEXGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV
  • 4. L13A028469    From 1 To 44 E-value: 2e-17 Score: 79.3
        LEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSV
  • 5. L13A027432    From 1 To 29 E-value: 0.000000002 Score: 52.8
        SSLLEKGLDGAKKAVGGLGKLGKDAVEDL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Tyler-Polsz C.,Reim D.,Speicher D.,Hodge L.,Cunningham T.J.,
  •   Title:Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin.
  •   Journal:J. Neurosci., 1998, 18, 7047-7060  [MEDLINE:98409756]
  •   [2]  Kalbacher H.,Bauer J.,Sauer B.,Hipfel R.,Schittek B.,
  •   Title:Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
  •   Journal:Nat. Immunol., 2001, 2, 1133-1137  [MEDLINE:21582109]
  •   [3]  Henzel W.J.,Zhang Z.,
  •   Title:Signal peptide prediction based on analysis of experimentally verified cleavage sites.
  •   Journal:Protein Sci., 2004, 13, 2819-2824  [PubMed:15340161]
  •   [4]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]
  •   [5]  Cree A.,Chen R.,Buhay C.J.,Muzny D.M.,Scherer S.E.,
  •   Title:The finished DNA sequence of human chromosome 12.
  •   Journal:Nature, 2006, 440, 346-351  [:]
  •   [6]  Miyagawa K.,Nakagama H.,Kim P.,Kim-Motoyama H.,Lee Motoyama J.P.,
  •   Title:Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity.
  •   Journal:Biochem. Biophys. Res. Commun., 2007, 357, 828-833  [PubMed:17448443]
  •   [7]  Rehman M.,Nielsen M.L.,Gnad F.,Kumar C.,Choudhary C.,
  •   Title:Lysine acetylation targets protein complexes and co-regulates major cellular functions.
  •   Journal:Science, 2009, 325, 834-840  [PubMed:19608861]
  •   [8]  Lee J.Y.,Lee S.,Sim J.Y.,Yang S.T.,Jung H.H.,
  •   Title:Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles.
  •   Journal:BMB Rep., 2010, 43, 362-368  [PubMed:20510021]
  •   [9]  Buerckstuemmer T.,Breitwieser F.P.,Kaupe I.,Planyavsky M.,Burkard T.R.,
  •   Title:Initial characterization of the human central proteome.
  •   Journal:BMC Syst. Biol., 2011, 5, 17-17  [PubMed:21269460]

Comments

  •   Comments

    •     No comments found on LAMP database



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