Record in detail


General Info

  • lamp_id:L01A000262
  • Name:HEPC_MORCS
  • FullName:Hepcidin
  • Source:Morone chrysops x Morone saxatilis
  • Mass:2263.7 Da
  • Sequence Length:21 aa
  • Isoelectric Point:7.97
  • Activity:Antibacterial
  • Sequence
        GCRFCCNCCPNMSGCGVCCRF
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000171    From 65 To 85 E-value: 0.0000001 Score: 46.6
        GCRFCCNCCPNMSGCGVCCRF
  • 2. L01A000262    From 1 To 21 E-value: 0.000002 Score: 42.4
        GCRFCCNCCPNMSGCGVCCRF
  • 3. L12A08273|    From 68 To 88 E-value: 0.000004 Score: 41.6
        GCRFCCGCCPNMRGCGVCCRF
  • 4. L12A08269|    From 68 To 88 E-value: 0.000005 Score: 41.2
        GCRFCCGCCPNMIGCGVCCRF
  • 5. L12A08291|    From 69 To 88 E-value: 0.000009 Score: 40.4
        CKFCCNCCPGMSGCGVCCRF

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Carlberg J.M.,Ostland V.E.,Westerman M.E.,Lauth X.,Shike H.,
  •   Title:Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.
  •   Journal:Eur. J. Biochem., 2002, 269, 2232-2237  [MEDLINE:21982021]
  •   [2]  Nizet V.,Singh S.,Stannard J.A.,Babon J.J.,Lauth X.,
  •   Title:Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.
  •   Journal:J. Biol. Chem., 2005, 280, 9272-9282  [PubMed:15546886]

Comments

  •   Comments

    •     No comments found on LAMP database



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