Record in detail

General Info

lamp_id:L01A000265
Name:PS2_PSEPD
FullName:Pseudin-2
Source:Pseudis paradoxa
Mass:2685.2 Da
Sequence Length:24 aa
Isoelectric Point:10.51
Activity:Antibacterial, Antifungal
Sequence
GLNALKKVFQGIHEAIKLINNHVQ
Function:Possesses antifungal activity against C.albicans and is also active against E.coli and S.aureus. Also has low hemolytic activity against human erythrocytes.

Cross-Linking

Cross-linking
1 Database:APD 476
2 Database:CAMP CAMPSQ243
3 Database:DBAASP 3355
4 Database:dbAMP dbAMP_03696
5 Database:DRAMP DRAMP02285
6 Database:SATPdb satpdb26169
7 Database:Uniprot P83189
8 Database:AMD PSE2_PSEPA

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000265 From 1 To 24 E-value: 0.00000003 Score: 48.9
GLNALKKVFQGIHEAIKLINNHVQ
2. L11A006933 From 1 To 24 E-value: 0.00000007 Score: 47.8
GLNAFKKVFQGIHEAIKLINNHVQ
3. L11A006937 From 1 To 24 E-value: 0.00000008 Score: 47.4
GLNALKKVFQGIHEAIKLFNNHVQ
4. L11A006936 From 1 To 24 E-value: 0.00000008 Score: 47.4
GLNALKKVFQGIHEAFKLINNHVQ
5. L11A006935 From 1 To 24 E-value: 0.00000008 Score: 47.4
GLNALKKVFQGFHEAIKLINNHVQ

Structure

Domains
1 Name:Antimicrobial_19 Interpro Link:IPR013156

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 21.4816 μg/ml (8 μM)
2 Target: S. aureus MIC: 85.9264 μg/ml (32 μM)

Toxicity

Toxicity

Reference

Reference
[1] Conlon J.M.,Knoop F.C.,Soto A.M.,Olson L. III,
Title:Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.
Journal:Biochem. Biophys. Res. Commun., 2001, 288, 1001-1005 [MEDLINE:21547799]

Comments

Comments