Record in detail

lamp_id:L01A000269
Name:TOP1_OXYTA
FullName:M-oxotoxin-Ot1a
Source:Oxyopes takobius
Mass:5221.3 Da
Sequence Length:48 aa
Isoelectric Point:11.92
Activity:Antibacterial
Sequence
FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ
Function:Disrupts cell membranes, particularly those rich in phosphocholine, through formation of pores. Has antimicrobial activity against Gram-negative bacterium E.coli, Gram-positive bacteria B.subtilis and S.aureus, and hemolytic activity against sheep, pig and guinea pig erythrocytes. Has insecticidal activity against S.frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides.

Top similar AMPs on LAMP
1. L01A000269 From 1 To 48 E-value: 4e-21 Score: 91.7
FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ
2. L12A07247| From 39 To 68 E-value: 3.5 Score: 22.3
RGLFSILKIGAKVIG---KNLLKQAGKAGMEYA
3. L12A06977| From 39 To 68 E-value: 4.7 Score: 21.6
RGLFSILKIGAKVIG---KSLLKQAGKAGMEYA
4. L12A07012| From 39 To 68 E-value: 5.7 Score: 21.6
RGLFSILKIG----AEVIGKNLLKQAGKAGMEYA
5. L12A07243| From 39 To 75 E-value: 6.7 Score: 21.2
RGIFSLFKAGAKFFG---KHLLKQAGKAG-------AEHLACKATNQ

Reference
[1] Belokoneva O.S.,Possani L.D.,Gomez-Lagunas F.,Villegas E.,Corzo G.,
Title:Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.
Journal:J. Biol. Chem., 2002, 277, 23627-23637 [MEDLINE:22075178]
[2] Villegas E.,Pal"mina N.P.,Mal"tseva E.L.,Satake H.,Belokoneva O.S.,
Title:Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.
Journal:Biochim. Biophys. Acta, 2004, 1664, 182-188 [PubMed:15328050]