Record in detail

lamp_id:L01A000272
Name:TOP2C_OXYTA
FullName:M-oxotoxin-Ot2c
Source:Oxyopes takobius
Mass:4064.8 Da
Sequence Length:37 aa
Isoelectric Point:11.25
Activity:Antibacterial
Sequence
GKLSGISKVLRAIAKFFKGVGKARKQFKEASDLDKNQ
Function:Disrupts biological membranes, particularly those rich in phosphocholine. Has antimicrobial activity against Gram-negative bacterium E.coli, Gram-positive bacteria B.subtilis and S.aureus, and hemolytic activity against sheep, pig and guinea pig red blood cells. Has insecticidal activity against S.frugiperda ovarian cells by opening non-selective ion channels. Enhances the insecticidal activity of spider venom neurotoxic peptides.

Top similar AMPs on LAMP
1. L01A000272 From 1 To 37 E-value: 0.000000000000003 Score: 72
GKLSGISKVLRAIAKFFKGVGKARKQFKEASDLDKNQ
2. L01A000271 From 1 To 37 E-value: 0.000000000003 Score: 62.4
GKFSGFAKILKSIAKFFKGVGKVRKQFKEASDLDKNQ
3. L13A029180 From 1 To 37 E-value: 0.000000000007 Score: 60.8
GKFSGFAKILKSIAKFFKGVGKVRKQFKQASDLDKNQ
4. L02A000774 From 1 To 37 E-value: 0.00000000002 Score: 59.7
GKFSGFAKILKSIAKFFKGVGKVRKGFKEASDLDKNQ
5. L01A000273 From 1 To 37 E-value: 0.00000000008 Score: 57.4
GKFSVFSKILRSIAKVFKGVGKVRKQFKTASDLDKNQ

Reference
[1] Belokoneva O.S.,Possani L.D.,Gomez-Lagunas F.,Villegas E.,Corzo G.,
Title:Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.
Journal:J. Biol. Chem., 2002, 277, 23627-23637 [MEDLINE:22075178]