Record in detail


General Info

  • lamp_id:L01A000280
  • Name:M1H1_BOMMX
  • FullName:Maximins 1/H1
  • Source:Bombina maxima
  • Mass:1934.4 Da
  • Sequence Length:20 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial, Antifungal,Anticancer
  • Sequence
        ILGPVISTIGGVLGGLLKNL
  • Function:Maximin-1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity. It shows high spermicidal activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000280    From 1 To 20 E-value: 0.0001 Score: 37
        ILGPVISTIGGVLGGLLKNL
  • 2. L13A022149    From 1 To 19 E-value: 0.0002 Score: 35.8
        ILGPVISTIGGVLGGLLKN
  • 3. L01A003335    From 1 To 20 E-value: 0.0003 Score: 35.4
        ILGPVIKTIGGVLGGLLKNL
  • 4. L13A014180    From 1 To 20 E-value: 0.0003 Score: 35
        ILGPVISTIGNVLGGLLKNL
  • 5. L01A000729    From 1 To 20 E-value: 0.0004 Score: 35
        ILGPVISKIGGVLGGLLKNL

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Escherichia coli ATCC25922  MIC:  9 μg/ml  (4.65261 μM)  
  •   2  Target:  Staphylococcus aureus ATCC2592  MIC:  4.5 μg/ml  (2.3263 μM)  
  •   3  Target:  Bacillus pyocyaneus CMCCB1010  MIC:  9 μg/ml  (4.65261 μM)  
  •   4  Target:  Candida albicans ATCC2002  MIC:  4.5 μg/ml  (2.3263 μM)  
  •   5  Target:  E. coli  MIC:  9.0143 μg/ml  (4.66 μM)  
  •   6  Target:  S. aureus  MIC:  4.50715 μg/ml  (2.33 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
  •   Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
  •   Journal:Peptides, 2002, 23, 427-435  [MEDLINE:21826911]
  •   [2]  Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
  •   Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
  •   Journal:Eur. J. Immunol., 2005, 35, 1220-1229  [PubMed:15770703]

Comments

  •   Comments

    •     No comments found on LAMP database



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