Record in detail

lamp_id:L01A000281
Name:M2H1_BOMMX
FullName:Maximins 2/H1
Source:Bombina maxima
Mass:2703.2 Da
Sequence Length:27 aa
Isoelectric Point:10.48
Activity:Antibacterial, Antifungal
Sequence
GIGTKILGGVKTALKGALKELASTYVN
Function:Maximin-2 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity.

Top similar AMPs on LAMP
1. L01A000281 From 1 To 27 E-value: 0.000000004 Score: 52
GIGTKILGGVKTALKGALKELASTYVN
2. L12A08586| From 44 To 69 E-value: 0.000000006 Score: 51.2
GIGTKILGGVKTALKGALKELASTYV
3. L02A001731 From 1 To 27 E-value: 0.00000001 Score: 50.4
GIGTKFLGGVKTALKGALKELASTYVN
4. L12A08576| From 44 To 70 E-value: 0.00000001 Score: 50.4
GIGTKIIGGLKTAVKGALKELASTYVN
5. L13A018172 From 2 To 27 E-value: 0.00000001 Score: 50.1
IGTKILGGVKTALKGALKELASTYVN

Antibacterial Activities
1 Target: Escherichia coli ATCC25922 MIC: 19.5 μg/ml (7.21367 μM)
2 Target: Staphylococcus aureus ATCC2592 MIC: 19.5 μg/ml (7.21367 μM)
3 Target: Bacillus pyocyaneus CMCCB10104 MIC: 19.5 μg/ml (7.21367 μM)
4 Target: Bacillus megatherium MIC: 19.5 μg/ml (7.21367 μM)
5 Target: Bacillus dysenteriae MIC: 2.7 μg/ml (0.998816 μM)
6 Target: Klebsiella pneumoniae MIC: 9 μg/ml (3.32939 μM)
7 Target: Candida albicans ATCC2002 MIC: 3 μg/ml (1.1098 μM)
8 Target: E. coli MIC: 19.5171 μg/ml (7.22 μM)
9 Target: S. aureus MIC: 19.5171 μg/ml (7.22 μM)

Reference
[1] Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
Journal:Peptides, 2002, 23, 427-435 [MEDLINE:21826911]
[2] Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
Journal:Eur. J. Immunol., 2005, 35, 1220-1229 [PubMed:15770703]