Record in detail


General Info

  • lamp_id:L01A000282
  • Name:M3H2_BOMMX
  • FullName:Maximins 3/H2
  • Source:Bombina maxima
  • Mass:2698.2 Da
  • Sequence Length:27 aa
  • Isoelectric Point:10.48
  • Activity:Antibacterial, Antifungal, Antiviral,Anticancer
  • Sequence
        GIGGKILSGLKTALKGAAKELASTYLH
  • Function:Maximin-3 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It possess a significant anti-HIV activity. It shows high spermicidal activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000282    From 1 To 27 E-value: 0.000000005 Score: 51.6
        GIGGKILSGLKTALKGAAKELASTYLH
  • 2. L13A029157    From 1 To 27 E-value: 0.00000001 Score: 50.1
        GIGGKILSGLKTALKGAAKELAATYLH
  • 3. L13A021428    From 1 To 27 E-value: 0.00000002 Score: 49.3
        GIGGKILSGFKTALKGAAKELAATYLH
  • 4. L13A026153    From 1 To 27 E-value: 0.00000002 Score: 49.3
        GIGGKILSGLKTALKGAAKELAFTYLH
  • 5. L13A026050    From 1 To 27 E-value: 0.00000003 Score: 49.3
        GIGGKILSGLKTALKGAAKQLAATYLH

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Escherichia coli ATCC25922  MIC:  0.9 μg/ml  (0.333556 μM)  
  •   2  Target:  Staphylococcus aureus ATCC2592  MIC:  3.1 μg/ml  (1.14891 μM)  
  •   3  Target:  Bacillus pyocyaneus CMCCB10104  MIC:  1.5 μg/ml  (0.555926 μM)  
  •   4  Target:  Bacillus megatherium  MIC:  0.9 μg/ml  (0.333556 μM)  
  •   5  Target:  Bacillus dysenteriae  MIC:  0.9 μg/ml  (0.333556 μM)  
  •   6  Target:  Klebsiella pneumoniae  MIC:  3.1 μg/ml  (1.14891 μM)  
  •   7  Target:  Candida albicans ATCC2002  MIC:  15 μg/ml  (5.55926 μM)  
  •   8  Target:  HIV-1  MIC:  11.4 μg/ml  (4.22504 μM)  
  •   9  Target:  E. coli  MIC:  9.4437 μg/ml  (3.5 μM)  
  •   10  Target:  S. aureus  MIC:  4.69487 μg/ml  (1.74 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
  •   Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
  •   Journal:Peptides, 2002, 23, 427-435  [MEDLINE:21826911]
  •   [2]  Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
  •   Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
  •   Journal:Eur. J. Immunol., 2005, 35, 1220-1229  [PubMed:15770703]

Comments

  •   Comments

    •     No comments found on LAMP database



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