Record in detail
General Info
- lamp_id:L01A000286
- Name:M5H41_BOMMX
- FullName:Maximins 5/H4 type 1
- Source:Bombina maxima
- Mass:2841.4 Da
- Sequence Length:27 aa
- Isoelectric Point:10.48
- Activity:Antibacterial, Antifungal, Antiviral,Anticancer
- Sequence
SIGAKILGGVKTFFKGALKELASTYLQ - Function:Maximin-5 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. The only exception is the resistance of E.coli. Shows also antimicrobial activity against fungi C.albicans, A.flavus and P.uticale. It has little hemolytic activity. It does not possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity.
Cross-Linking
- Cross-linking
- 1 Database:APD 62
- 2 Database:CAMP CAMPSQ263
- 3 Database:DBAASP 843
- 4 Database:dbAMP dbAMP_11035
- 5 Database:DRAMP DRAMP01111
- 6 Database:SATPdb satpdb20882
- 7 Database:Uniprot P83084
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000286 From 1 To 27 E-value: 0.000000001 Score: 53.1
SIGAKILGGVKTFFKGALKELASTYLQ - 2. L13A027382 From 1 To 27 E-value: 0.000000009 Score: 50.8
SIGAKVLGGVKTFFKGALKELASTYQQ - 3. L02A001741 From 1 To 27 E-value: 0.00000001 Score: 50.4
SIGAKILGGVKTFFKGALKELAFTYLQ - 4. L01A002858 From 2 To 27 E-value: 0.000001 Score: 43.9
IGAKILGGVKTALKGALKELASTYVN - 5. L12A08586| From 45 To 69 E-value: 0.000002 Score: 42.7
IGTKILGGVKTALKGALKELASTYV
Activity
- Antibacterial Activities
- 1 Target: Staphylococcus aureus ATCC2592 MIC: 3.6 μg/ml (1.26698 μM)
- 2 Target: Bacillus pyocyaneus CMCCB10104 MIC: 7.2 μg/ml (2.53396 μM)
- 3 Target: Bacillus megatherium MIC: 12 μg/ml (4.22327 μM)
- 4 Target: Bacillus dysenteriae MIC: 12 μg/ml (4.22327 μM)
- 5 Target: Klebsiella pneumoniae MIC: 3.6 μg/ml (1.26698 μM)
- 6 Target: Candida albicans ATCC2002 MIC: 1.2 μg/ml (0.422327 μM)
- 7 Target: Aspergillus flavus IFFI4015 MIC: 12 μg/ml (4.22327 μM)
- 8 Target: Penicillium uticale IFFI2001 MIC: 12 μg/ml (4.22327 μM)
- 9 Target: HIV-1 MIC: 34.4 μg/ml (12.1067 μM)
- 10 Target: S. aureus MIC: 3.60858 μg/ml (1.27 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
- Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
- Journal:Peptides, 2002, 23, 427-435 [MEDLINE:21826911]
- [2] Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
- Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
- Journal:Eur. J. Immunol., 2005, 35, 1220-1229 [PubMed:15770703]
Comments
- Comments
No comments found on LAMP database