Record in detail

lamp_id:L01A000294
Name:THAN_PODMA
FullName:Thanatin
Source:Podisus maculiventris
Mass:2435.9 Da
Sequence Length:21 aa
Isoelectric Point:11.09
Activity:Antibacterial, Antifungal
Sequence
GSKKPVPIIYCNRRTGKCQRM
Function:Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes.

Top similar AMPs on LAMP
1. L11A012528 From 19 To 39 E-value: 0.0000001 Score: 46.6
GSKKPVPIIYCNRRTGKCQRM
2. L01A000294 From 1 To 21 E-value: 0.0000002 Score: 46.2
GSKKPVPIIYCNRRTGKCQRM
3. L13A021933 From 1 To 21 E-value: 0.0000004 Score: 45.1
GSKKPVPIIYCNRRSGKCQRM
4. L11A007137 From 1 To 21 E-value: 0.0000004 Score: 44.7
GSKKPVPIIYCNRRTAKCQRM
5. L11A007136 From 1 To 21 E-value: 0.0000007 Score: 44.3
GSKKPVPIIYCQRRTGKCQRM

Antibacterial Activities
1 Target: A. viridans MIC: 1.46 μg/ml (0.599368 μM)
2 Target: M. luteus MIC: 2.92 μg/ml (1.19874 μM)
3 Target: B. megaterium MIC: 6.09 μg/ml (2.5001 μM)
4 Target: B. subtilis MIC: 6.09 μg/ml (2.5001 μM)
5 Target: P.acidolactici MIC: 48.72 μg/ml (20.0008 μM)
6 Target: E. coli D22 MIC: 0.73 μg/ml (0.299684 μM)
7 Target: E. coli D31 MIC: 0.73 μg/ml (0.299684 μM)
8 Target: E. coli 1106 MIC: 1.46 μg/ml (0.599368 μM)
9 Target: S.typhimurium MIC: 1.46 μg/ml (0.599368 μM)
10 Target: K.pneumoniae MIC: 1.46 μg/ml (0.599368 μM)
11 Target: E.cloacae MIC: 2.92 μg/ml (1.19874 μM)
12 Target: E.carotovora MIC: 24.36 μg/ml (10.0004 μM)
13 Target: P.aeuroginosa MIC: 48.72 μg/ml (20.0008 μM)
14 Target: N.crassa MIC: 1.46 μg/ml (0.599368 μM)
15 Target: B.cinerea MIC: 2.92 μg/ml (1.19874 μM)
16 Target: N.haematococca MIC: 2.92 μg/ml (1.19874 μM)
17 Target: T.viride MIC: 2.92 μg/ml (1.19874 μM)
18 Target: A.brassicola MIC: 6.09 μg/ml (2.5001 μM)
19 Target: F.culmorum MIC: 6.09 μg/ml (2.5001 μM)
20 Target: A.pisi MIC: 12.18 μg/ml (5.00021 μM)
21 Target: F.oxysporum MIC: 24.36 μg/ml (10.0004 μM)

Reference
[1] Roussel J.-P.,Briand J.-P.,Chernysh S.,Bulet P.,Fehlbaum P.,
Title:Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
Journal:Proc. Natl. Acad. Sci. U.S.A., 1996, 93, 1221-1225 [MEDLINE:96165548]
[2] Bulet P.,Bonmatin J.-M.,Labbe H.,Sodano P.,Mandard N.,
Title:Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data.
Journal:Eur. J. Biochem., 1998, 256, 404-410 [MEDLINE:98430981]