Record in detail

lamp_id:L01A000301
Name:H2A_BUFBG
FullName:Histone H2A
Source:Bufo bufo gargarizans
Mass:2434.9 Da
Sequence Length:21 aa
Isoelectric Point:13.11
Activity:Antibacterial, Antifungal,Anticancer
Sequence
TRSSRAGLQFPVGRVHRLLRK
Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Top similar AMPs on LAMP
1. L12A11014| From 16 To 36 E-value: 0.0000006 Score: 44.3
TRSSRAGLQFPVGRVHRLLRK
2. L12A11015| From 16 To 36 E-value: 0.0000006 Score: 44.3
TRSSRAGLQFPVGRVHRLLRK
3. L12A11013| From 16 To 36 E-value: 0.0000006 Score: 44.3
TRSSRAGLQFPVGRVHRLLRK
4. L12A11012| From 16 To 36 E-value: 0.0000007 Score: 44.3
TRSSRAGLQFPVGRVHRLLRK
5. L01A002852 From 16 To 36 E-value: 0.0000007 Score: 44.3
TRSSRAGLQFPVGRVHRLLRK

Antibacterial Activities
1 Target: Bacillus subtilis MIC: 2 μg/ml (0.821389 μM)
2 Target: Staphylococcus aureus MIC: 4 μg/ml (1.64278 μM)
3 Target: Streptococcus mutans MIC: 2 μg/ml (0.821389 μM)
4 Target: Streptococcus pneumoniae MIC: 4 μg/ml (1.64278 μM)
5 Target: Pseudomonas putida MIC: 2 μg/ml (0.821389 μM)
6 Target: Escherichia coli MIC: 4 μg/ml (1.64278 μM)
7 Target: Salmonella typhimurium MIC: 1 μg/ml (0.410695 μM)
8 Target: Serratia sp. MIC: 4 μg/ml (1.64278 μM)
9 Target: Candida albicans MIC: 1 μg/ml (0.410695 μM)
10 Target: Cryptococcus neoformans MIC: 1 μg/ml (0.410695 μM)
11 Target: E. coli MIC: 3.89584 μg/ml (1.6 μM)
12 Target: S. aureus MIC: 3.89584 μg/ml (1.6 μM)