Record in detail

lamp_id:L01A000303
Name:SPYY_PHYBI
FullName:Skin peptide tyrosine-tyrosine
Source:Phyllomedusa bicolor
Mass:2909.3 Da
Sequence Length:23 aa
Isoelectric Point:9.78
Activity:Antibacterial, Antifungal
Sequence
PEEMNKYLTALRHYINLVTRQRY
Function:Shows a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, yeast and fungi.

Top similar AMPs on LAMP
1. L02A000400 From 14 To 36 E-value: 0.000000009 Score: 50.4
PEEMNKYLTALRHYINLVTRQRY
2. L01A000303 From 1 To 23 E-value: 0.00000001 Score: 49.7
PEEMNKYLTALRHYINLVTRQRY
3. L11A004190 From 14 To 36 E-value: 0.000005 Score: 41.2
PEELNRYYASLRHYLNLVTRQRY
4. L02A001474 From 15 To 36 E-value: 0.00002 Score: 39.3
EDMARYYSALRHYINLITRQRY
5. L13A020613 From 15 To 36 E-value: 0.00007 Score: 37.7
EDLARYYSALRHYINLITRQRY

Antibacterial Activities
1 Target: Aeromonas caviae MIC: 40 μg/ml (13.749 μM)
2 Target: Escherichia coli MIC: 10 μg/ml (3.43725 μM)
3 Target: Enterococcus faecalis MIC: 10 μg/ml (3.43725 μM)
4 Target: Nocardia brasiliensis MIC: 20 μg/ml (6.87451 μM)
5 Target: Cryptococcus neoformans MIC: 20 μg/ml (6.87451 μM)
6 Target: Candida albicans MIC: 15 μg/ml (5.15588 μM)
7 Target: Microsporum canis MIC: 10 μg/ml (3.43725 μM)
8 Target: Tricophyton rubrum MIC: 15 μg/ml (5.15588 μM)
9 Target: Arthroderma simii MIC: 10 μg/ml (3.43725 μM)
10 Target: Aspergillus fumigatus MIC: 80 μg/ml (27.498 μM)
11 Target: Aspergillus niger MIC: 100 μg/ml (34.3725 μM)

Reference
[1] Nicolas P.,Vaudry H.,Chartrel N.,Mor A.,
Title:Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.
Journal:Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 10295-10299 [MEDLINE:95024100]
[2] Mor A.,Nicolas P.,Shai Y.,Vouldoukis I.,
Title:Broad spectrum antibiotic activity of the skin-PYY.
Journal:FEBS Lett., 1996, 380, 237-240 [MEDLINE:96186932]