Record in detail


General Info

  • lamp_id:L01A000304
  • Name:RL1_HELPY
  • FullName:50S ribosomal protein L1
  • Source:Helicobacter pylori (strain ATCC 700392 / 26695)
  • Mass:2320.8 Da
  • Sequence Length:19 aa
  • Isoelectric Point:11.09
  • Activity:Antibacterial, Antifungal
  • Sequence
        AKKVFKRLEKLFSKIQNDK
  • Function:Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A00303|    From 1 To 19 E-value: 0.00005 Score: 37.7
        AKKVFKRLEKLFSKIQNDK
  • 2. L01A000304    From 1 To 19 E-value: 0.00005 Score: 37.7
        AKKVFKRLEKLFSKIQNDK
  • 3. L13A016260    From 1 To 19 E-value: 0.0002 Score: 35.8
        AKKVFKRLEKLFSKIWNDK
  • 4. L12A00305|    From 1 To 19 E-value: 0.0002 Score: 35.8
        AKKVFKRLEKLFSKIWNDK
  • 5. L13A011458    From 1 To 19 E-value: 0.0003 Score: 35.4
        AKKVFKRLEKSFSKIQNDK

Structure

  •   Domains
  •   1  Name:Ribosom_L1_bac-type    Interpro Link:IPR005878
  •   2  Name:Ribosomal_L1    Interpro Link:IPR002143
  •   3  Name:Ribosomal_L1_2-a/b-sand    Interpro Link:IPR016094
  •   4  Name:Ribosomal_L1_3-a/b-sand    Interpro Link:IPR016095
  •   5  Name:Ribosomal_L1_CS    Interpro Link:IPR023673
  •   6  Name:Ribosomal_L1_SF    Interpro Link:IPR023674
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  B. subtilis  MIC:  7.26 μg/ml  (3.12823 μM)  
  •   2  Target:  S. epidermidis  MIC:  14.51 μg/ml  (6.25215 μM)  
  •   3  Target:  S. aureus  MIC:  29.01 μg/ml  (12.5 μM)  
  •   4  Target:  E. coli  MIC:  7.26 μg/ml  (3.12823 μM)  
  •   5  Target:  S. typhimurium  MIC:  3.62 μg/ml  (1.55981 μM)  
  •   6  Target:  P. vulgaris  MIC:  6.25 μg/ml  (2.69304 μM)  
  •   7  Target:  P. aeruginosa  MIC:  14.51 μg/ml  (6.25215 μM)  
  •   8  Target:  E. coli O157  MIC:  29.01 μg/ml  (12.5 μM)  
  •   9  Target:  L. monocytogenes  MIC:  14.51 μg/ml  (6.25215 μM)  
  •   10  Target:  T. beigelii  MIC:  7.26 μg/ml  (3.12823 μM)  
  •   11  Target:  C. albicans  MIC:  58.02 μg/ml  (25 μM)  
  •   12  Target:  S. cerevisiae  MIC:  58.02 μg/ml  (25 μM)  
  •   13  Target:  A. flavus  MIC:  116.04 μg/ml  (50 μM)  
  •   14  Target:  A. fumigatus  MIC:  116.04 μg/ml  (50 μM)  
  •   15  Target:  F. moniliforme  MIC:  58.02 μg/ml  (25 μM)  
  •   16  Target:  B. cinerea  MIC:  29.01 μg/ml  (12.5 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Sutton G.G.,Clayton R.A.,Kerlavage A.R.,White O.,Tomb J.-F.,
  •   Title:The complete genome sequence of the gastric pathogen Helicobacter pylori.
  •   Journal:Nature, 1997, 388, 539-547  [MEDLINE:97394467]
  •   [2]  Normark S.,Boman H.G.,Branden C.I.,Putsep K.,
  •   Title:Antibacterial peptide from H. pylori.
  •   Journal:Nature, 1999, 398, 671-672  [MEDLINE:99241827]
  •   [3]  Taylor S.,Rothel L.,Radcliff F.,Webb E.,Hocking D.,
  •   Title:Isolation of recombinant protective Helicobacter pylori antigens.
  •   Journal:Infect. Immun., 1999, 67, 4713-4719  [MEDLINE:99386867]
  •   [4]  Shin S.Y.,Kang D.-I.,Park Y.,Lee D.G.,Lee K.H.,
  •   Title:Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.
  •   Journal:Biochem. J., 2006, 394, 105-114  [PubMed:16255716]

Comments

  •   Comments

    •     No comments found on LAMP database



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