Record in detail

lamp_id:L01A000318
Name:PAN1_PANIM
FullName:Pandinin-1
Source:Pandinus imperator
Mass:4799.5 Da
Sequence Length:44 aa
Isoelectric Point:10.49
Activity:Antibacterial
Sequence
GKVWDWIKSAAKKIWSSEPVSQLKGQVLNAAKNYVAEKIGATPT
Function:Disrupts cell membranes through formation of pores. Strong antimicrobial activity against Gram-positive bacteria B.subtilis, S.epidermidis, E.faecalis and S.aureus. Less active against Gram-negative bacteria P.aeruginosa and E.coli. Has no antifungal or hemolytic activity.

Top similar AMPs on LAMP
1. L01A000318 From 1 To 44 E-value: 6e-20 Score: 87.8
GKVWDWIKSAAKKIWSSEPVSQLKGQVLNAAKNYVAEKIGATPT
2. L01A000338 From 1 To 44 E-value: 0.000000000000002 Score: 72.8
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNFVAEKIGATPS
3. L12A08840| From 23 To 66 E-value: 0.000000000000002 Score: 72.8
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS
4. L01A002450 From 1 To 44 E-value: 0.000000000000006 Score: 71.2
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS
5. L01A000337 From 1 To 44 E-value: 0.000000000000007 Score: 71.2
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS

Antibacterial Activities
1 Target: P.aeruginosa MIC: 99.83 μg/ml (20.8001 μM)
2 Target: E. coli MIC: 99.83 μg/ml (20.8001 μM)
3 Target: Ent. faecalis MIC: 6.24 μg/ml (1.30014 μM)
4 Target: C. albicans MIC: 99.83 μg/ml (20.8001 μM)
5 Target: B. subtilis MIC: 24.96 μg/ml (5.20054 μM)
6 Target: Staph. epidermidis MIC: 24.96 μg/ml (5.20054 μM)
7 Target: Staph. aureus MIC: 12.48 μg/ml (2.60027 μM)

Reference
[1] He W.,Barnham K.J.,Villegas E.,Escoubas P.,Corzo G.,
Title:Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.
Journal:Biochem. J., 2001, 359, 35-45 [MEDLINE:21448116]
[2] Iwashita T.,Darbon H.,Nakajima T.,Ferrat G.,Nomura K.,
Title:Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.
Journal:Biophys. J., 2005, 89, 4067-4080 [PubMed:16199510]