Record in detail

lamp_id:L01A000319
Name:PAN2_PANIM
FullName:Pandinin-2
Source:Pandinus imperator
Mass:2612.1 Da
Sequence Length:24 aa
Isoelectric Point:10.8
Activity:Antibacterial
Sequence
FWGALAKGALKLIPSLFSSFSKKD
Function:Disrupts cell membranes through formation of pores. Has strong antimicrobial activity against Gram-positive bacteria B.subtilis, S.epidermidis, E.faecalis and S.aureus. Less active against Gram-negative bacteria P.aeruginosa and E.coli. Possesses antifungal activity against C.albicans and hemolytic activity against sheep and pig erythrocytes.

Top similar AMPs on LAMP
1. L01A000319 From 1 To 24 E-value: 0.00000006 Score: 47.8
FWGALAKGALKLIPSLFSSFSKKD
2. L12A08991| From 23 To 46 E-value: 0.0000001 Score: 47
FWGALAKGALKLIPSLVSSFTKKD
3. L13A015576 From 1 To 24 E-value: 0.0000004 Score: 45.1
FWGALAKGALKLIPSLVSSFTKKD
4. L13A019886 From 1 To 24 E-value: 0.0000005 Score: 44.7
FWGALAKGALKLIVSLFSSFSKKD
5. L12A02394| From 1 To 24 E-value: 0.0000007 Score: 44.3
FWGALAKGALKLIGSLFSSFSKKD

Antibacterial Activities
1 Target: P.aeruginosa MIC: 99.78 μg/ml (38.1992 μM)
2 Target: E. coli MIC: 49.89 μg/ml (19.0996 μM)
3 Target: Ent. faecalis MIC: 6.27 μg/ml (2.40037 μM)
4 Target: C. albicans MIC: 49.89 μg/ml (19.0996 μM)
5 Target: B. subtilis MIC: 12.54 μg/ml (4.80073 μM)
6 Target: Staph. epidermidis MIC: 12.54 μg/ml (4.80073 μM)
7 Target: Staph. aureus MIC: 6.27 μg/ml (2.40037 μM)

Reference
[1] He W.,Barnham K.J.,Villegas E.,Escoubas P.,Corzo G.,
Title:Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.
Journal:Biochem. J., 2001, 359, 35-45 [MEDLINE:21448116]
[2] Iwashita T.,Nakajima T.,Corzo G.,Nomura K.,
Title:Orientation and pore-forming mechanism of a scorpion pore-forming peptide bound to magnetically oriented lipid bilayers.
Journal:Biophys. J., 2004, 87, 2497-2507 [PubMed:15298871]
[3] Villegas E.,Pal"mina N.P.,Mal"tseva E.L.,Satake H.,Belokoneva O.S.,
Title:Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.
Journal:Biochim. Biophys. Acta, 2004, 1664, 182-188 [PubMed:15328050]