Record in detail
General Info
- lamp_id:L01A000322
- Name:AB27_CYPCA
- FullName:27 kDa antibacterial protein
- Source:Cyprinus carpio
- Mass:1966.1 Da
- Sequence Length:19 aa
- Isoelectric Point:3.83
- Activity:Antibacterial
- Sequence
GIGGKPVQTAFVDNDGIYD - Function:Has antibacterial activity. It inhibits fish bacterial pathogens, A.hydrophila and M.luteus, and also E.coli, P.fluorescens and S.aureus. Forms large ion channels responsible for disrupting the cellular envelope of bacteria leading to cell lysis.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ299
- 2 Database:dbAMP dbAMP_02939
- 3 Database:DRAMP DRAMP03153
- 4 Database:SATPdb satpdb18583
- 5 Database:Uniprot P81925
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000322 From 1 To 19 E-value: 0.000006 Score: 40.8
GIGGKPVQTAFVDNDGIYD
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: A. hydrophila MIC: 5 μg/ml (2.54311 μM)
- 2 Target: M. luteus MIC: 5 μg/ml (2.54311 μM)
- 3 Target: E. coli MIC: 5 μg/ml (2.54311 μM)
- 4 Target: P. fluorescens MIC: 10 μg/ml (5.08621 μM)
- 5 Target: S. aureus MIC: 5 μg/ml (2.54311 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Gagnon J.,Saint N.,Saglio P.,Orange N.,Lemaitre C.,
- Title:Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio).
- Journal:Eur. J. Biochem., 1996, 240, 143-149 [MEDLINE:96390874]
Comments
- Comments
No comments found on LAMP database