Record in detail


General Info

  • lamp_id:L01A000427
  • Name:DEF4_HUMAN
  • FullName:Neutrophil defensin 4
  • Source:Homo sapiens
  • Mass:3715.4 Da
  • Sequence Length:33 aa
  • Isoelectric Point:8.63
  • Activity:Antibacterial, Antifungal
  • Sequence
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • Function:Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A09030|    From 64 To 96 E-value: 0.00000000000002 Score: 69.7
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • 2. L01A000836    From 64 To 96 E-value: 0.00000000000002 Score: 69.3
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • 3. L01A003040    From 1 To 33 E-value: 0.0000000000004 Score: 65.1
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • 4. L01A000427    From 1 To 33 E-value: 0.0000000000005 Score: 65.1
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • 5. L12A08994|    From 67 To 97 E-value: 0.012 Score: 30.4
        TCYCRSSFCKFGELPSGTCTLNGIRYRFCCS

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   3  Name:Defensin_propep    Interpro Link:IPR002366
  •   4  Name:Mammalian_defensins    Interpro Link:IPR006081
  •   Structures
  •   1
    PDB:1ZMM
    Method:X-ray
    Chains:A/B/C/D=64-96

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Esch F.,Shimasaki S.,Zhu Q.,Bateman A.,Singh A.,
  •   Title:Structure of a novel human granulocyte peptide with anti-ACTH activity.
  •   Journal:Biochem. Biophys. Res. Commun., 1988, 155, 524-529  [MEDLINE:88326354]
  •   [2]  Wilde C.,Griffith J.,Campanelli D.,Scott R.W.,Gabay J.E.,
  •   Title:Antibiotic proteins of human polymorphonuclear leukocytes.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1989, 86, 5610-5614  [MEDLINE:89315847]
  •   [3]  Scott R.W.,Snable J.L.,Marra M.N.,Griffith J.E.,Wilde C.G.,
  •   Title:Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family.
  •   Journal:J. Biol. Chem., 1989, 264, 11200-11203  [MEDLINE:89291867]
  •   [4]  Solomon S.,Sadro L.C.,Palfree R.G.E.,
  •   Title:The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8.
  •   Journal:Mol. Endocrinol., 1993, 7, 199-205  [MEDLINE:93225961]
  •   [5]  Lehrer R.I.,Lu W.,Wu Z.,Ericksen B.,
  •   Title:Antibacterial activity and specificity of the six human alpha-defensins.
  •   Journal:Antimicrob. Agents Chemother., 2005, 49, 269-275  [PubMed:15616305]
  •   [6]  Lubkowski J.,Ericksen B.,Gentles D.,Cocchi F.,Wu Z.,
  •   Title:Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.
  •   Journal:FEBS Lett., 2005, 579, 162-166  [PubMed:15620707]
  •   [7]  Lu W.,Yang D.,Tucker K.,Wu Z.,Szyk A.,
  •   Title:Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
  •   Journal:Protein Sci., 2006, 15, 2749-2760  [PubMed:17088326]
  •   [8]  Lin J.,Parsons D.W.,Wood L.D.,Jones S.,Sjoeblom T.,
  •   Title:The consensus coding sequences of human breast and colorectal cancers.
  •   Journal:Science, 2006, 314, 268-274  [PubMed:16959974]

Comments

  •   Comments

    •     No comments found on LAMP database



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