Record in detail

General Info

lamp_id:L01A000444
Name:BR1PC_RANPI
FullName:Brevinin-1Pc
Source:Rana pipiens
Mass:2585.2 Da
Sequence Length:24 aa
Isoelectric Point:10.35
Activity:Antibacterial, Antifungal
Sequence
FLPIIASVAAKVFSKIFCAISKKC
Function:Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans.

Cross-Linking

Cross-linking
1 Database:APD 470
2 Database:CAMP CAMPSQ411
3 Database:DBAASP 1818
4 Database:dbAMP dbAMP_02040
5 Database:DRAMP DRAMP02098
6 Database:SATPdb satpdb11273
7 Database:Uniprot P82843

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000444 From 1 To 24 E-value: 0.0000002 Score: 45.8
FLPIIASVAAKVFSKIFCAISKKC
2. L12A09649| From 21 To 44 E-value: 0.0000005 Score: 45.1
FLPIIASVAAKVFPKIFCAISKKC
3. L12A09653| From 21 To 44 E-value: 0.0000005 Score: 44.7
FLPIIAGVAAKVFPKIFCAISKKC
4. L01A000445 From 1 To 24 E-value: 0.0000006 Score: 44.7
FLPIIASVAANVFSKIFCAISKKC
5. L01A000446 From 1 To 24 E-value: 0.0000008 Score: 43.9
FLPIIASVAAKVFPKIFCAISKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 12.926 μg/ml (5 μM)
2 Target: S. aureus MIC: 18.0964 μg/ml (7 μM)

Toxicity

Toxicity

Reference

Reference
[1] Knoop F.C.,O"Flaherty M.,Li Z.,Wang Y.,Goraya J.,
Title:Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
Journal:Eur. J. Biochem., 2000, 267, 894-900 [MEDLINE:20117700]

Comments

Comments