Record in detail

General Info

lamp_id:L01A000470
Name:RLCA_RANCL
FullName:Ranalexin-1Ca
Source:Rana clamitans
Mass:2111.7 Da
Sequence Length:20 aa
Isoelectric Point:9.67
Activity:Antibacterial, Antifungal
Sequence
FLGGLMKAFPALICAVTKKC
Function:Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has activity against C.albicans.

Cross-Linking

Cross-linking
1 Database:APD 514
2 Database:CAMP CAMPSQ437
3 Database:DBAASP 1020
4 Database:dbAMP dbAMP_01927
5 Database:DRAMP DRAMP01356
6 Database:SATPdb satpdb26196
7 Database:Uniprot P82876

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000470 From 1 To 20 E-value: 0.000003 Score: 42
FLGGLMKAFPALICAVTKKC
2. L01A000471 From 1 To 20 E-value: 0.000005 Score: 41.2
FLGGLMKAFPAIICAVTKKC
3. L03A000117 From 47 To 66 E-value: 0.0001 Score: 36.6
FLGGLIKIVPAMICAVTKKC
4. L11A009230 From 1 To 20 E-value: 0.0003 Score: 35.4
FLGGLIKIVPAMICAVTKKC
5. L01A000650 From 1 To 20 E-value: 0.0003 Score: 35.4
FLGGLIKIVPAMICAVTKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: S.aureus MIC: 35.9 μg/ml (17.0005 μM)
2 Target: E.coli MIC: 8.45 μg/ml (4.00152 μM)
3 Target: C.albicans MIC: 29.56 μg/ml (13.9982 μM)
4 Target: E. coli MIC: 8.4468 μg/ml (4 μM)
5 Target: S. aureus MIC: 35.8989 μg/ml (17 μM)

Toxicity

Toxicity

Reference

Reference
[1] Conlon J.M.,Knoop F.C.,Basir Y.J.,Halverson T.,
Title:Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.
Journal:Peptides, 2000, 21, 469-476 [MEDLINE:20283865]

Comments

Comments