Record in detail
General Info
- lamp_id:L01A000485
- Name:CTHL1_BOVIN
- FullName:Cathelicidin-1
- Source:Bos taurus
- Mass:1485.9 Da
- Sequence Length:12 aa
- Isoelectric Point:12.02
- Activity:Antibacterial
- Sequence
RLCRIVVIRVCR - Function:Potent microbicidal activity; active against S.aureus and E.coli.
Cross-Linking
- Cross-linking
- 1 Database:APD 8
- 2 Database:CAMP CAMPSQ452
- 3 Database:DBAASP 1059
- 4 Database:dbAMP dbAMP_10549
- 5 Database:DRAMP DRAMP02851
- 6 Database:SATPdb satpdb27940
- 7 Database:Uniprot P22226
- 8 Database:AMD BCT1_BOVIN
- 9 Database:RAP RAPD0010
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000485 From 1 To 12 E-value: 0.7 Score: 23.5
RLCRIVVIRVCR - 2. L11A001063 From 2 To 13 E-value: 0.8 Score: 23.1
RLCRIVVIRVCR - 3. L11A013169 From 1 To 12 E-value: 2.4 Score: 21.6
RXCRIVVIRVCR - 4. L11A013161 From 1 To 12 E-value: 2.7 Score: 21.6
KLCKIVVIKVCK - 5. L11A013168 From 1 To 12 E-value: 3.1 Score: 21.2
RKCRIVVIRVCR
Activity
- Antibacterial Activities
- 1 Target: S.aureus MIC: 1 μg/ml (0.672993 μM)
- 2 Target: E.coli MIC: 8 μg/ml (5.38394 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Gennaro R.,Bolognesi M.,Skerlavaj B.,Romeo D.,
- Title:Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils.
- Journal:J. Biol. Chem., 1988, 263, 9573-9575 [MEDLINE:88257074]
- [2] Zanetti M.,Schneider C.,del Sal G.,Storici P.,
- Title:cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils.
- Journal:FEBS Lett., 1992, 314, 187-190 [MEDLINE:93093170]
- [3] Romeo D.,Lenarcic B.,Tossi A.,Storici P.,
- Title:Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.
- Journal:Eur. J. Biochem., 1996, 238, 769-776 [MEDLINE:96300243]
Comments
- Comments
No comments found on LAMP database