Record in detail

General Info

lamp_id:L01A000486
Name:BR1_RANBP
FullName:Brevinin-1
Source:Rana brevipoda porsa
Mass:2531.2 Da
Sequence Length:24 aa
Isoelectric Point:10.35
Activity:Antibacterial
Sequence
FLPVLAGIAAKVVPALFCKITKKC
Function:Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity.

Cross-Linking

Cross-linking
1 Database:APD 74
2 Database:CAMP CAMPSQ453
3 Database:DBAASP 3008
4 Database:dbAMP dbAMP_02165
5 Database:DRAMP DRAMP02009
6 Database:SATPdb satpdb21470
7 Database:Uniprot P32423
8 Database:AMD BR1_RANBP

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000486 From 1 To 24 E-value: 0.00000007 Score: 47.8
FLPVLAGIAAKVVPALFCKITKKC
2. L13A013879 From 1 To 24 E-value: 0.000003 Score: 42
FLPIIAGMAAKVIPSLFCAITKKC
3. L02A001438 From 1 To 24 E-value: 0.000005 Score: 41.6
FFPIIAGMAAKLIPSLFCKITKKC
4. L12A09639| From 21 To 44 E-value: 0.000005 Score: 41.6
FLPIIAGVAAKVLPKLFCAITKKC
5. L03A000024 From 1 To 24 E-value: 0.000007 Score: 40.8
FLPVIAGIAANVLPKLFCKLTKRC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: S. aureus MIC: 8 μg/ml (3.16056 μM)
2 Target: E. coli MIC: 34 μg/ml (13.4324 μM)

Toxicity

Toxicity

Reference

Reference
[1] Nakajima T.,Hagiwara K.,Morikawa N.,
Title:Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa.
Journal:Biochem. Biophys. Res. Commun., 1992, 189, 184-190 [MEDLINE:93080555]

Comments

Comments