Record in detail
General Info
- lamp_id:L01A000489
- Name:ATTC_DROME
- FullName:Attacin-C
- Source:Drosophila melanogaster
- Mass:2785.2 Da
- Sequence Length:23 aa
- Isoelectric Point:10.11
- Activity:Antibacterial, Antifungal
- Sequence
QRPYTQPLIYYPPPPTPPRIYRA - Function:Has antimicrobial activity in synergy with other peptides. Strongest activity observed against E.cloacae.
Cross-Linking
- Cross-linking
- 1 Database:APD 1566
- 2 Database:CAMP CAMPSQ456
- 3 Database:dbAMP dbAMP_10255
- 4 Database:DRAMP DRAMP03099
- 5 Database:SATPdb satpdb28544
- 6 Database:Uniprot Q95NH6
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000489 From 1 To 23 E-value: 0.0000008 Score: 43.9
QRPYTQPLIYYPPPPTPPRIYRA - 2. L11A001080 From 2 To 23 E-value: 0.000003 Score: 42
RPYTQPLIYYPPPPTPPRIYRA
Activity
- Antibacterial Activities
- 1 Target: Agrobacterium tumefaciens MIC: 557.04 μg/ml (200 μM)
- 2 Target: Enterobacter cloacae b12 MIC: 557.04 μg/ml (200 μM)
- 3 Target: Escherichia coli SBS 363 MIC: 557.04 μg/ml (200 μM)
- 4 Target: Escherichia coli D31 MIC: 557.04 μg/ml (200 μM)
- 5 Target: Escherichia coli D22 MIC: 557.04 μg/ml (200 μM)
- 6 Target: Erwinia carotovora carotovora MIC: 557.04 μg/ml (200 μM)
- 7 Target: Pseudomonas aeruginosa MIC: 557.04 μg/ml (200 μM)
- 8 Target: Salmonella typhimurium MIC: 557.04 μg/ml (200 μM)
- 9 Target: Serratia marcescens MIC: 557.04 μg/ml (200 μM)
- 10 Target: Bacillus megaterium MIC: 557.04 μg/ml (200 μM)
- 11 Target: Micrococcus luteus MIC: 557.04 μg/ml (200 μM)
- 12 Target: Staphylococcus aureus MIC: 557.04 μg/ml (200 μM)
- 13 Target: Streptococcus pyogenes MIC: 557.04 μg/ml (200 μM)
- 14 Target: Neurospora crassa MIC: 557.04 μg/ml (200 μM)
- 15 Target: Aspergillus fumigatus MIC: 557.04 μg/ml (200 μM)
- 16 Target: Candida albicans MIC: 557.04 μg/ml (200 μM)
- 17 Target: Candida glabrata MIC: 557.04 μg/ml (200 μM)
- 18 Target: Cryptococcus neoformans MIC: 557.04 μg/ml (200 μM)
- 19 Target: Saccharomyces cerevisiae MIC: 557.04 μg/ml (200 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Hoffmann J.A.,van Dorsselaer A.,Lagueux M.,Moniatte M.,Uttenweiler-Joseph S.,
- Title:Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1998, 95, 11342-11347 [MEDLINE:98409659]
- [2] Hultmark D.,Borge K.,Hedengren M.,
- Title:Expression and evolution of the Drosophila attacin/diptericin gene family.
- Journal:Biochem. Biophys. Res. Commun., 2000, 279, 574-581 [MEDLINE:20568719]
- [3] Gocayne J.D.,Evans C.A.,Holt R.A.,Celniker S.E.,Adams M.D.,
- Title:The genome sequence of Drosophila melanogaster.
- Journal:Science, 2000, 287, 2185-2195 [MEDLINE:20196006]
- [4] Clark A.G.,Lazzaro B.P.,
- Title:Evidence for recurrent paralogous gene conversion and exceptional allelic divergence in the attacin genes of Drosophila melanogaster.
- Journal:Genetics, 2001, 159, 659-671 [MEDLINE:21518597]
- [5] Campbell K.S.,Matthews B.B.,Mungall C.J.,Crosby M.A.,Misra S.,
- Title:Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426069]
- [6] Cudic M.,Cavicchioli L.,Ehret-Sabatier L.,Charlet M.,Rabel D.,
- Title:Primary structure and in vitro antibacterial properties of the Drosophila melanogaster attacin C Pro-domain.
- Journal:J. Biol. Chem., 2004, 279, 14853-14859 [PubMed:14744858]
- [7] Gygi S.P.,Mintseris J.,Beausoleil S.A.,Villen J.,Zhai B.,
- Title:Phosphoproteome analysis of Drosophila melanogaster embryos.
- Journal:J. Proteome Res., 2008, 7, 1675-1682 [PubMed:18327897]
Comments
- Comments
No comments found on LAMP database