Record in detail

lamp_id:L01A000492
Name:ES1_RANES
FullName:Esculentin-1
Source:Rana esculenta
Mass:4887.9 Da
Sequence Length:46 aa
Isoelectric Point:10.58
Activity:Antibacterial, Antifungal
Sequence
GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
Function:Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

Top similar AMPs on LAMP
1. L01A000492 From 1 To 46 E-value: 6e-20 Score: 87.8
GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
2. L01A003317 From 1 To 46 E-value: 1e-19 Score: 86.7
GIFSKFGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
3. L12A04132| From 25 To 70 E-value: 9e-19 Score: 84
GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
4. L03A000115 From 39 To 84 E-value: 1e-18 Score: 83.6
GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
5. L12A04130| From 25 To 70 E-value: 1e-18 Score: 83.2
GIFSKLAGKKIKNLLISGLKNIGKEVGMDVVRTGIDIAGCKIKGEC

Antibacterial Activities
1 Target: E.coliD21 MIC: 0.98 μg/ml (0.200495 μM)
2 Target: B. megaterrum Bm11 MIC: 0.49 μg/ml (0.100248 μM)
3 Target: S.aureus Cowan1 MIC: 1.96 μg/ml (0.40099 μM)
4 Target: P.aeruginosaATCC15692 MIC: 3.42 μg/ml (0.699687 μM)
5 Target: C.albicans MIC: 2.44 μg/ml (0.499192 μM)
6 Target: S. cerevisiae MIC: 4.4 μg/ml (0.900182 μM)

Reference
[1] Bossa F.,Barra D.,Mignogna G.,Simmaco M.,
Title:Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta.
Journal:FEBS Lett., 1993, 324, 159-161 [MEDLINE:93285327]