Record in detail


General Info

  • lamp_id:L01A000493
  • Name:TRFL_BOVIN
  • FullName:Lactotransferrin
  • Source:Bos taurus
  • Mass:3125.8 Da
  • Sequence Length:25 aa
  • Isoelectric Point:12.35
  • Activity:Antibacterial,Anticancer
  • Sequence
        FKCRRWQWRMKKLGAPSITCVRRAF
  • Function:Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000018    From 1 To 25 E-value: 0.0000000007 Score: 54.3
        FKCRRWQWRMKKLGAPSITCVRRAF
  • 2. L01A002629    From 5 To 29 E-value: 0.0000000009 Score: 53.9
        FKCRRWQWRMKKLGAPSITCVRRAF
  • 3. L13A015192    From 1 To 25 E-value: 0.0000000009 Score: 53.9
        FKCRRWQWRMKKLGAPSITCVRRAF
  • 4. L12A05621|    From 21 To 45 E-value: 0.000000001 Score: 53.9
        FKCRRWQWRMKKLGAPSITCVRRAF
  • 5. L01A002630    From 2 To 26 E-value: 0.000000001 Score: 53.9
        FKCRRWQWRMKKLGAPSITCVRRAF

Structure

  •   Domains
  •   1  Name:Peptidase_S60    Interpro Link:IPR001156
  •   2  Name:Transferrin    Interpro Link:IPR016357
  •   3  Name:Transferrin_Fe_BS    Interpro Link:IPR018195
  •   Structures
  •   1
    PDB:1BLF
    Method:X-ray
    Chains:A=20-708
  •   2
    PDB:1LFC
    Method:NMR
    Chains:A=36-60
  •   3
    PDB:1NKX
    Method:X-ray
    Chains:A=361-708
  •   4
    PDB:1SDX
    Method:X-ray
    Chains:A=361-695, E=700-704
  •   5
    PDB:1Y58
    Method:NMR
    Chains:A=38-49
  •   6
    PDB:2ALU
    Method:X-ray
    Chains:A=361-708
  •   7
    PDB:2AYS
    Method:X-ray
    Chains:A=361-708
  •   8
    PDB:2B65
    Method:X-ray
    Chains:A=361-705
  •   9
    PDB:2DOJ
    Method:X-ray
    Chains:A=361-705
  •   10
    PDB:2DP8
    Method:X-ray
    Chains:A=361-705
  •   11
    PDB:2DQV
    Method:X-ray
    Chains:A=361-705
  •   12
    PDB:2DS9
    Method:X-ray
    Chains:A=361-705
  •   13
    PDB:2DSF
    Method:X-ray
    Chains:A=361-705
  •   14
    PDB:2DVC
    Method:X-ray
    Chains:A=361-705
  •   15
    PDB:2DWA
    Method:X-ray
    Chains:A=361-705
  •   16
    PDB:2DWH
    Method:X-ray
    Chains:A=361-705
  •   17
    PDB:2DWI
    Method:X-ray
    Chains:A=361-705
  •   18
    PDB:2DWJ
    Method:X-ray
    Chains:A=361-705
  •   19
    PDB:2DXR
    Method:X-ray
    Chains:A=361-705
  •   20
    PDB:2DXY
    Method:X-ray
    Chains:A=361-705
  •   21
    PDB:2DYX
    Method:X-ray
    Chains:A=361-705
  •   22
    PDB:2E0S
    Method:X-ray
    Chains:A=361-705
  •   23
    PDB:2E1S
    Method:X-ray
    Chains:A=361-705
  •   24
    PDB:2FA7
    Method:X-ray
    Chains:A=361-705
  •   25
    PDB:2G93
    Method:X-ray
    Chains:A=361-705
  •   26
    PDB:2H4I
    Method:X-ray
    Chains:A=361-705
  •   27
    PDB:2HCA
    Method:X-ray
    Chains:A=361-705
  •   28
    PDB:2NUV
    Method:X-ray
    Chains:A=361-705
  •   29
    PDB:2NWJ
    Method:X-ray
    Chains:A=361-705
  •   30
    PDB:2O1L
    Method:X-ray
    Chains:A=361-705
  •   31
    PDB:2O51
    Method:X-ray
    Chains:A=361-705
  •   32
    PDB:2OCU
    Method:X-ray
    Chains:A=361-705
  •   33
    PDB:2P1S
    Method:X-ray
    Chains:A=361-704
  •   34
    PDB:2PX1
    Method:X-ray
    Chains:A=361-705
  •   35
    PDB:2Q8J
    Method:X-ray
    Chains:A=361-708
  •   36
    PDB:2QJE
    Method:X-ray
    Chains:A=361-708
  •   37
    PDB:2R71
    Method:X-ray
    Chains:A=361-705
  •   38
    PDB:2R9J
    Method:X-ray
    Chains:A=361-705
  •   39
    PDB:2ZMB
    Method:X-ray
    Chains:A=361-705
  •   40
    PDB:3CFL
    Method:X-ray
    Chains:A=361-705
  •   41
    PDB:3CI8
    Method:X-ray
    Chains:A=361-705
  •   42
    PDB:3CRB
    Method:X-ray
    Chains:A=361-705
  •   43
    PDB:3E9X
    Method:X-ray
    Chains:A=361-705
  •   44
    PDB:3IAZ
    Method:X-ray
    Chains:A=361-705
  •   45
    PDB:3IB0
    Method:X-ray
    Chains:A=361-705
  •   46
    PDB:3IB1
    Method:X-ray
    Chains:A=361-705
  •   47
    PDB:3IB2
    Method:X-ray
    Chains:A=361-705
  •   48
    PDB:3K0V
    Method:X-ray
    Chains:A=361-705
  •   49
    PDB:3KJ7
    Method:X-ray
    Chains:A=361-705
  •   50
    PDB:3MJN
    Method:X-ray
    Chains:A=361-705
  •   51
    PDB:3O97
    Method:X-ray
    Chains:A=361-705
  •   52
    PDB:3RGY
    Method:X-ray
    Chains:A=361-705
  •   53
    PDB:3SDF
    Method:X-ray
    Chains:A=361-705
  •   54
    PDB:3TAJ
    Method:X-ray
    Chains:A=361-705
  •   55
    PDB:3TOD
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   56
    PDB:3TTR
    Method:X-ray
    Chains:A=361-705
  •   57
    PDB:3TUS
    Method:X-ray
    Chains:A=361-705
  •   58
    PDB:3U72
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   59
    PDB:3U8Q
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   60
    PDB:3UGW
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   61
    PDB:3UK4
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   62
    PDB:3USD
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   63
    PDB:3V5A
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   64
    PDB:3VDF
    Method:X-ray
    Chains:A=361-695
  •   65
    PDB:4DIG
    Method:X-ray
    Chains:A=361-695, B=700-705
  •   66
    PDB:4DXU
    Method:X-ray
    Chains:A=361-695

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli  MIC:  12.5 μg/ml  (3.99898 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Giardi M.F.,Turacchio M.,Di Nino G.,Giansanti F.,Massucci M.T.,
  •   Title:
  •   Journal:BioMetals, 2004, 17, 745-745  [:]
  •   [2]  Hurley W.L.,Hegarty H.M.,Rejman J.J.,
  •   Title:Purification and characterization of bovine lactoferrin from secretions of the involuting mammary gland: identification of multiple molecular weight forms.
  •   Journal:Comp. Biochem. Physiol., 1989, 93, 929-934  [MEDLINE:90031466]
  •   [3]  Schanbacher F.L.,Goodman R.E.,
  •   Title:Bovine lactoferrin mRNA: sequence, analysis, and expression in the mammary gland.
  •   Journal:Biochem. Biophys. Res. Commun., 1991, 180, 75-84  [MEDLINE:92028986]
  •   [4]  Schmidt A.M.,Pan Y.C.E.,Wang F.,Burns D.K.,Tsang T.C.,
  •   Title:Cloning of a 80-kD advanced glycosylation end product (AGE) binding protein from bovine lung.
  •   Journal:FASEB J., 1991, 6, 233-233  [:]
  •   [5]  Tartar A.,Maes P.,Benaissa M.,Colavizza D.,Pierce A.,
  •   Title:Molecular cloning and sequence analysis of bovine lactotransferrin.
  •   Journal:Eur. J. Biochem., 1991, 196, 177-184  [MEDLINE:91160550]
  •   [6]  Hobom G.,Koczan D.,Interthal H.,Tuckoricz A.,Seyfert H.-M.,
  •   Title:Structure of the bovine lactoferrin-encoding gene and its promoter.
  •   Journal:Gene, 1994, 143, 265-269  [MEDLINE:94266164]
  •   [7]  Smith R.,Dionysius D.A.,Grieve P.A.,Milne J.M.,Hoek K.S.,
  •   Title:Antibacterial activity in bovine lactoferrin-derived peptides.
  •   Journal:Antimicrob. Agents Chemother., 1997, 41, 54-59  [PubMed:8980754]
  •   [8]  Baker E.N.,Haridas M.,Groom C.R.,Anderson B.F.,Moore S.A.,
  •   Title:Three-dimensional structure of diferric bovine lactoferrin at 2.8-A resolution.
  •   Journal:J. Mol. Biol., 1997, 274, 222-236  [MEDLINE:98062367]
  •   [9]  Vogel H.J.,Arrowsmith C.H.,Shan X.,Zhou N.,Hwang P.M.,
  •   Title:Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin.
  •   Journal:Biochemistry, 1998, 37, 4288-4298  [MEDLINE:98190007]
  •   [10]  Kaartinen L.,Saloniemi H.,Pyorala S.,Kutila T.,
  •   Title:Antibacterial effect of bovine lactoferrin against udder pathogens.
  •   Journal:Acta Vet. Scand., 2003, 44, 35-42  [PubMed:14650542]
  •   [11]  Giardi M.F.,Turacchio M.,Di Nino G.,Giansanti F.,Massucci M.T.,
  •   Title:Proteolytic activity of bovine lactoferrin.
  •   Journal:BioMetals, 2004, 17, 249-255  [PubMed:15222473]

Comments

  •   Comments

    •     No comments found on LAMP database



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