Record in detail
General Info
- lamp_id:L01A000500
- Name:DMS4_PHYSA
- FullName:Dermaseptin-4
- Source:Phyllomedusa sauvagei
- Mass:2779.4 Da
- Sequence Length:27 aa
- Isoelectric Point:11.28
- Activity:Antibacterial, Antifungal, Antiviral
- Sequence
ALWMTLLKKVLKAAAKALNAVLVGANA - Function:Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity. Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite. Kills the parasite, and only at high concentrations has an hemolytic activity on the host cell.
Cross-Linking
- Cross-linking
- 1 Database:APD 160
- 2 Database:CAMP CAMPSQ467
- 3 Database:DBAASP 5531
- 4 Database:dbAMP dbAMP_00400
- 5 Database:DRAMP DRAMP01671
- 6 Database:SATPdb satpdb15949
- 7 Database:Uniprot P80280
- 8 Database:AMD DMS4_PHYSA
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000500 From 1 To 27 E-value: 0.00000004 Score: 48.5
ALWMTLLKKVLKAAAKALNAVLVGANA - 2. L13A023103 From 1 To 16 E-value: 0.01 Score: 30.4
ALWMTLLKKVLKAAAK - 3. L13A020656 From 1 To 16 E-value: 0.074 Score: 27.7
ALWKTLLKKVLKAAAK - 4. L13A014616 From 1 To 16 E-value: 0.074 Score: 27.7
ALWKTLLKKVLKAAAK - 5. L03A000103 From 45 To 71 E-value: 0.13 Score: 26.9
ALWKTLLKKVGKVAGKAVLNAVTNMAN
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Nicolas P.,Mor A.,
- Title:Isolation and structure of novel defensive peptides from frog skin.
- Journal:Eur. J. Biochem., 1994, 219, 145-154 [MEDLINE:94139686]
- [2] Mazier D.,Ciceron L.,Guillaud P.,Shaool D.,Ghosh J.K.,
- Title:Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis.
- Journal:J. Biol. Chem., 1997, 272, 31609-31616 [PubMed:9395500]
- [3] Mor A.,Nehushtai R.,Feder R.,
- Title:Affinity driven molecular transfer from erythrocyte membrane to target cells.
- Journal:Peptides, 2001, 22, 1683-1690 [PubMed:11587797]
- [4] Mor A.,Carmeli Y.,Gaidukov L.,Feder R.,Navon-Venezia S.,
- Title:Antibacterial properties of dermaseptin S4 derivatives with in vivo activity.
- Journal:Antimicrob. Agents Chemother., 2002, 46, 689-694 [PubMed:11850249]
- [5] Mor A.,Ginsburg H.,Gaidukov L.,Dagan A.,Efron L.,
- Title:Direct interaction of dermaseptin S4 aminoheptanoyl derivative with intraerythrocytic malaria parasite leading to increased specific antiparasitic activity in culture.
- Journal:J. Biol. Chem., 2002, 277, 24067-24072 [PubMed:11937508]
- [6] Jemmali M.,Trabelsi A.,Khelifa R.,Aouni M.,Belaid A.,
- Title:In vitro antiviral activity of dermaseptins against herpes simplex virus type 1.
- Journal:J. Med. Virol., 2002, 66, 229-234 [PubMed:11782932]
- [7] Brack-Werner R.,Graessmann A.,Mor A.,Feder R.,Hariton-Gazal E.,
- Title:Targeting of nonkaryophilic cell-permeable peptides into the nuclei of intact cells by covalently attached nuclear localization signals.
- Journal:Biochemistry, 2002, 41, 9208-9214 [PubMed:12119035]
- [8] Baleux F.,Zairi A.,Belaid A.,Saidi H.,Lorin C.,
- Title:The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.
- Journal:Virology, 2005, 334, 264-275 [PubMed:15780876]
- [9] Mor A.,Fish A.,Rotem S.,Shalev D.E.,
- Title:Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13).
- Journal:J. Biol. Chem., 2006, 281, 9432-9438 [PubMed:16407175]
- [10] Mor A.,Radzishevsky I.,Rotem S.,
- Title:Physicochemical properties that enhance discriminative antibacterial activity of short dermaseptin derivatives.
- Journal:Antimicrob. Agents Chemother., 2006, 50, 2666-2672 [PubMed:16870756]
Comments
- Comments
No comments found on LAMP database