Record in detail
General Info
- lamp_id:L01A000516
- Name:RACYT_RANTE
- FullName:Ranacyclin-T
- Source:Rana temporaria
- Mass:1892.3 Da
- Sequence Length:17 aa
- Isoelectric Point:10.14
- Activity:Antibacterial, Antifungal
- Sequence
GALRGCWTKSYPPKPCK - Function:Has antibacterial activity against Gram-positive bacteria B.megaterium Bm11, S.lentus and M.luteus, and Gram-negative bacteria E.coli D22, Y.pseudotuberculosis YP III and P.syringae pv tabaci, and antifungal activity against C.albicans ATCC 10231, C.tropicalis, C.guiller-mondii and P.nicotianae spores. Has weak hemolytic activity. The mature peptide inserts into the hydrophobic core of the bacterial cell membrane and increases permeability without disrupting membrane integrity. Probably binds to the outer membrane surface before aggregating to form transmembrane pores.
Cross-Linking
- Cross-linking
- 1 Database:APD 1250
- 2 Database:CAMP CAMPSQ481
- 3 Database:DBAASP 2167
- 4 Database:dbAMP dbAMP_02429
- 5 Database:DRAMP DRAMP02275
- 6 Database:SATPdb satpdb19209
- 7 Database:Uniprot P83719
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A07353| From 44 To 60 E-value: 0.000004 Score: 41.6
GALRGCWTKSYPPKPCK - 2. L01A000516 From 1 To 17 E-value: 0.00003 Score: 38.5
GALRGCWTKSYPPKPCK - 3. L13A011229 From 2 To 16 E-value: 0.0002 Score: 35.4
ALRGCWTKSYPPKPC - 4. L13A021190 From 2 To 16 E-value: 0.0002 Score: 35.4
ALRGCWTKSYPPKPC - 5. L12A07115| From 45 To 58 E-value: 0.0004 Score: 34.7
VRGCWTKSYPPKPC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Shai Y.,Andreu D.,Mignogna G.,Papo N.,Mangoni M.L.,
- Title:Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action and parameters involved in target specificity.
- Journal:Biochemistry, 2003, 42, 14023-14035 [PubMed:14636071]
Comments
- Comments
No comments found on LAMP database