Record in detail

lamp_id:L01A000520
Name:LYT1_HOGCA
FullName:M-lycotoxin-Hc1a
Source:Hogna carolinensis
Mass:2844.5 Da
Sequence Length:25 aa
Isoelectric Point:11.41
Activity:Antibacterial, Antifungal
Sequence
IWLTALKFLGKHAAKHLAKQQLSKL
Function:Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. Is lethal to lepidopteran larvae. May function both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion.

Top similar AMPs on LAMP
1. L01A000520 From 1 To 25 E-value: 0.00000003 Score: 48.9
IWLTALKFLGKHAAKHLAKQQLSKL
2. L13A029166 From 1 To 24 E-value: 0.00000008 Score: 47.8
IWLTALKFLGKHAAKHLAKQQLSK
3. L13A015543 From 1 To 25 E-value: 0.000003 Score: 42.4
IWLTALKFLGKNLGKHLAKQQLAKL
4. L11A011337 From 1 To 24 E-value: 0.0004 Score: 35
IWLTALKFLGKNLGK-LAKQQLAKL
5. L12A11985| From 1 To 21 E-value: 0.003 Score: 32.3
VWLSALKFIGKHLAKH----QLSKL

Reference
[1] Adams M.E.,Yan L.,
Title:Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.
Journal:J. Biol. Chem., 1998, 273, 2059-2066 [PubMed:9442044]
[2] Sterner D.E.,Panavas T.,Hector R.E.,Dowd P.F.,Hughes S.R.,
Title:Lycotoxin-1 insecticidal peptide optimized by amino acid scanning mutagenesis and expressed as a coproduct in an ethanologenic Saccharomyces cerevisiae strain.
Journal:J. Pept. Sci., 2008, 14, 1039-1050 [PubMed:18465835]
[3] Bastos M.,Pessoa J.C.,Gomes P.,Seixas R.,Adao R.,
Title:Membrane structure and interactions of a short Lycotoxin I analogue.
Journal:J. Pept. Sci., 2008, 14, 528-534 [PubMed:18098329]