Record in detail


General Info

  • lamp_id:L01A000521
  • Name:LYT2_HOGCA
  • FullName:M-lycotoxin-Hc2a
  • Source:Hogna carolinensis
  • Mass:3206.9 Da
  • Sequence Length:27 aa
  • Isoelectric Point:11.02
  • Activity:Antibacterial, Antifungal
  • Sequence
        KIKWFKTMKSIAKFIAKEQMKKHLGGE
  • Function:Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. May function both in the prey capture strategy as well as protection from infectious organisms arising from prey ingestion (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000521    From 1 To 27 E-value: 0.0000000009 Score: 53.9
        KIKWFKTMKSIAKFIAKEQMKKHLGGE
  • 2. L01A002472    From 1 To 25 E-value: 0.00000005 Score: 48.5
        KIKWFKTMKSLAKFLAKEQMKKHLG
  • 3. L13A022267    From 4 To 24 E-value: 0.00009 Score: 37.4
        WFKAMKSIAKFIAKEKLKEHL
  • 4. L11A004041    From 1 To 15 E-value: 5.7 Score: 21.6
        MKSIAKFIAKTVAKQ

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Adams M.E.,Yan L.,
  •   Title:Lycotoxins, antimicrobial peptides from venom of the wolf spider Lycosa carolinensis.
  •   Journal:J. Biol. Chem., 1998, 273, 2059-2066  [PubMed:9442044]
  •   [2]  Bastos M.,Pessoa J.C.,Gomes P.,Seixas R.,Adao R.,
  •   Title:Membrane structure and interactions of a short Lycotoxin I analogue.
  •   Journal:J. Pept. Sci., 2008, 14, 528-534  [PubMed:18098329]

Comments

  •   Comments

    •     No comments found on LAMP database



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