Record in detail


General Info

  • lamp_id:L01A000522
  • Name:DFB4A_HUMAN
  • FullName:Beta-defensin 4A
  • Source:Homo sapiens
  • Mass:4334.2 Da
  • Sequence Length:41 aa
  • Isoelectric Point:9.19
  • Activity:Antibacterial
  • Sequence
        GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
  • Function:Has antibacterial activity (Potential).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A001369    From 24 To 64 E-value: 3e-19 Score: 85.5
        GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
  • 2. L01A000522    From 1 To 41 E-value: 1e-18 Score: 83.6
        GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
  • 3. L03A000299    From 24 To 64 E-value: 2e-18 Score: 82.8
        GIGDPVTCLKNGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
  • 4. L05ADEF127    From 1 To 41 E-value: 2e-18 Score: 82.8
        GIGDPVTCLKNGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
  • 5. L01A001370    From 24 To 64 E-value: 3e-18 Score: 82.4
        GISDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP

Structure

  •   Domains
  •   1  Name:Defensin_beta-typ    Interpro Link:IPR001855
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   Structures
  •   1
    PDB:1E4Q
    Method:NMR
    Chains:A=28-64
  •   2
    PDB:1FD3
    Method:X-ray
    Chains:A/B/C/D=24-64
  •   3
    PDB:1FD4
    Method:X-ray
    Chains:A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/
  •   4
    PDB:1FQQ
    Method:NMR
    Chains:A=24-64

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli D31  MIC:  62 μg/ml  (14.3048 μM)  
  •   2  Target:  E.coli ATCC  MIC:  62 μg/ml  (14.3048 μM)  
  •   3  Target:  Pseudomonas aeruginosa ATCC  MIC:  62 μg/ml  (14.3048 μM)  
  •   4  Target:  Staphylococcus aureus ATCC  MIC:  62 μg/ml  (14.3048 μM)  
  •   5  Target:  E. faecalis ATCC  MIC:  15 μg/ml  (3.46085 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Schroeder J.-M.,Christophers E.,Bartels J.H.,Harder J.,
  •   Title:A peptide antibiotic from human skin.
  •   Journal:Nature, 1997, 387, 861-861  [MEDLINE:97345625]
  •   [2]  Heng H.H.Q.,Zhao C.,Jia H.P.,Wang L.,Liu L.,
  •   Title:Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.
  •   Journal:Gene, 1998, 222, 237-244  [MEDLINE:99051334]
  •   [3]  Bartels J.,Schwichtenberg L.,Teran L.M.,Meyer-Hoffert U.,Harder J.,
  •   Title:Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia.
  •   Journal:Am. J. Respir. Cell Mol. Biol., 2000, 22, 714-721  [PubMed:10837369]
  •   [4]  Oppenheim J.J.,Puri A.,Blumenthal R.,Rajashankar K.R.,Hoover D.M.,
  •   Title:The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
  •   Journal:J. Biol. Chem., 2000, 275, 32911-32918  [MEDLINE:20490730]
  •   [5]  Bevins C.L.,Russell J.P.,Rhodes J.,Kaiser V.,Diamond G.,
  •   Title:Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells.
  •   Journal:Infect. Immun., 2000, 68, 113-119  [MEDLINE:20072673]
  •   [6]  Forssmann W.-G.,Conejo-Garcia J.-R.,Kluever E.,Schweimer K.,Bauer F.,
  •   Title:Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
  •   Journal:Protein Sci., 2001, 10, 2470-2479  [MEDLINE:21571984]
  •   [7]  Adermann K.,Forssmann W.-G.,Schulz A.,Kluever E.,
  •   Title:Chemical synthesis of beta-defensins and LEAP-1/hepcidin.
  •   Journal:J. Pept. Res., 2002, 59, 241-248  [MEDLINE:22007551]
  •   [8]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]

Comments

  •   Comments

    •     No comments found on LAMP database



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