Record in detail

lamp_id:L01A000530
Name:CR11_LITSP
FullName:Caerin-1.1
Source:Litoria splendida
Mass:2585.1 Da
Sequence Length:25 aa
Isoelectric Point:7.81
Activity:Antibacterial, Antiviral,Anticancer
Sequence
GLLSVLGSVAKHVLPHVVPVIAEHL
Function:Antibacterial and antiviral peptides that adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.

Top similar AMPs on LAMP
1. L12A06176| From 50 To 74 E-value: 0.00000002 Score: 49.7
GLLSVLGSVAKHVLPHVVPVIAEHL
2. L12A06177| From 50 To 74 E-value: 0.00000002 Score: 49.7
GLLSVLGSVAKHVLPHVVPVIAEHL
3. L01A000530 From 1 To 25 E-value: 0.00000009 Score: 47.4
GLLSVLGSVAKHVLPHVVPVIAEHL
4. L01A002368 From 1 To 25 E-value: 0.0000002 Score: 46.2
GLLSVLGSVAQHVLPHVVPVIAEHL
5. L13A010626 From 1 To 24 E-value: 0.0000002 Score: 46.2
GLLSVLGSVAKHVLPHVVPVIAEH

Antibacterial Activities
1 Target: Bacillus cereus MIC: 50 μg/ml (19.3416 μM)
2 Target: Leuconostoc lactis MIC: 1.5 μg/ml (0.580248 μM)
3 Target: Listeria innocua MIC: 25 μg/ml (9.6708 μM)
4 Target: Micrococcus luteus MIC: 12.5 μg/ml (4.8354 μM)
5 Target: Pasteurella multocida MIC: 25 μg/ml (9.6708 μM)
6 Target: Staphylococcus aureus MIC: 3 μg/ml (1.1605 μM)
7 Target: Staphylococcus epidermis MIC: 12.5 μg/ml (4.8354 μM)
8 Target: Streptococcus uberis MIC: 12.5 μg/ml (4.8354 μM)
9 Target: S. aureus MIC: 2.99872 μg/ml (1.16 μM)

Reference
[1] Tyler M.J.,Wallace J.C.,Bowie J.H.,Waugh R.J.,Stone D.J.M.,
Title:Peptides from Australian frogs. Structures of the caerins and caeridin 1 from Litoria splendida.
Journal:J. Chem. Soc. Perkin Trans. I, 1992, 1, 3173-3178 [:]
[2] Carver J.A.,Bowie J.H.,Wong H.,
Title:The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.
Journal:Eur. J. Biochem., 1997, 247, 545-557 [MEDLINE:97409981]