Record in detail

General Info

lamp_id:L01A000535
Name:BR1YA_RANBO
FullName:Brevinin-1BYa
Source:Rana boylii
Mass:2609.3 Da
Sequence Length:24 aa
Isoelectric Point:10.35
Activity:Antibacterial, Antifungal,Anticancer
Sequence
FLPILASLAAKFGPKLFCLVTKKC
Function:Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. High antifungal activity against C.albicans and a strong hemolytic activity.

Cross-Linking

Cross-linking
1 Database:APD 878
2 Database:CAMP CAMPSQ499
3 Database:DBAASP 3536
4 Database:dbAMP dbAMP_02051
5 Database:DRAMP DRAMP01960
6 Database:SATPdb satpdb17760
7 Database:Uniprot P84111
8 Database:AMD BR1BYA_RANBO

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000535 From 1 To 24 E-value: 0.00000006 Score: 48.1
FLPILASLAAKFGPKLFCLVTKKC
2. L01A000536 From 1 To 24 E-value: 0.0000002 Score: 46.2
FLPILASLAAKLGPKLFCLVTKKC
3. L11A004418 From 1 To 24 E-value: 0.000001 Score: 43.5
FLPILASLAAKFGPKLFSLVTKKS
4. L11A004419 From 1 To 23 E-value: 0.000002 Score: 42.7
FLPILASLAAKFGPKLFXLVTKK
5. L01A000537 From 1 To 24 E-value: 0.000003 Score: 42.4
FLPILASLAATLGPKLLCLITKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 52.186 μg/ml (20 μM)
2 Target: S. aureus MIC: 6.52325 μg/ml (2.5 μM)

Toxicity

Toxicity

Reference

Reference
[1] Nielsen P.F.,Davidson C.,Patel M.,Sonnevend A.,Conlon J.M.,
Title:Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
Journal:J. Pept. Res., 2003, 62, 207-213 [PubMed:14531844]

Comments

Comments