Record in detail

General Info

lamp_id:L01A000536
Name:BR1YB_RANBO
FullName:Brevinin-1BYb
Source:Rana boylii
Mass:2575.2 Da
Sequence Length:24 aa
Isoelectric Point:10.35
Activity:Antibacterial, Antifungal
Sequence
FLPILASLAAKLGPKLFCLVTKKC
Function:Antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli. Has moderate antifungal activity against C.albicans and strong hemolytic activity.

Cross-Linking

Cross-linking
1 Database:APD 885
2 Database:CAMP CAMPSQ500
3 Database:DBAASP 3537
4 Database:dbAMP dbAMP_02052
5 Database:DRAMP DRAMP01961
6 Database:SATPdb satpdb23016
7 Database:Uniprot P84112

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000536 From 1 To 24 E-value: 0.00000008 Score: 47.4
FLPILASLAAKLGPKLFCLVTKKC
2. L01A000535 From 1 To 24 E-value: 0.0000002 Score: 46.2
FLPILASLAAKFGPKLFCLVTKKC
3. L01A000537 From 1 To 24 E-value: 0.000002 Score: 43.1
FLPILASLAATLGPKLLCLITKKC
4. L11A004418 From 1 To 24 E-value: 0.000004 Score: 41.6
FLPILASLAAKFGPKLFSLVTKKS
5. L11A004419 From 1 To 23 E-value: 0.000009 Score: 40.8
FLPILASLAAKFGPKLFXLVTKK

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 41.2032 μg/ml (16 μM)
2 Target: S. aureus MIC: 10.3008 μg/ml (4 μM)

Toxicity

Toxicity

Reference

Reference
[1] Nielsen P.F.,Davidson C.,Patel M.,Sonnevend A.,Conlon J.M.,
Title:Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii.
Journal:J. Pept. Res., 2003, 62, 207-213 [PubMed:14531844]

Comments

Comments