Record in detail
General Info
- lamp_id:L01A000545
- Name:RTD1B_MACMU
- FullName:Rhesus theta defensin-1/2 subunit B
- Source:Macaca mulatta
- Mass:2112.6 Da
- Sequence Length:18 aa
- Isoelectric Point:9.29
- Activity:Antibacterial
- Sequence
GVCRCLCRRGVCRCLCRR - Function:RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ509
- 2 Database:DBAASP 824
- 3 Database:dbAMP dbAMP_04206
- 4 Database:SATPdb satpdb13896
- 5 Database:Uniprot P82271
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000545 From 1 To 18 E-value: 0.001 Score: 33.5
GVCRCLCRRGVCRCLCRR - 2. L13A014365 From 1 To 18 E-value: 0.002 Score: 32.7
GVCRCLCRRGVCRCICRR - 3. L11A003857 From 1 To 18 E-value: 0.004 Score: 31.2
GVCRCVCRRGVCRCVCRR - 4. L13A012692 From 1 To 18 E-value: 0.01 Score: 30
GFCRCLCRRGVCRCLCTK - 5. L01A000660 From 1 To 18 E-value: 0.012 Score: 30
GFCRCLCRRGVCRCICTR
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Tran D.,Oesapay K.,Oesapay G.,Yuan J.,Tang Y.-Q.,
- Title:A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
- Journal:Science, 1999, 286, 498-502 [MEDLINE:99453140]
- [2] Nguyen T.,Hong T.,Aleshina G.,Kokryakov V.N.,Leonova L.,
- Title:Circular minidefensins and posttranslational generation of molecular diversity.
- Journal:J. Leukoc. Biol., 2001, 70, 461-464 [PubMed:11527997]
- [3] Cole T.,Yuan J.,Tang Y.-Q.,Tran P.A.,Tran D.,
- Title:Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides.
- Journal:J. Biol. Chem., 2002, 277, 3079-3084 [PubMed:11675394]
Comments
- Comments
No comments found on LAMP database