Record in detail


General Info

  • lamp_id:L01A000548
  • Name:APD22_APIME
  • FullName:Apidaecins type 22
  • Source:Apis mellifera
  • Mass:2108.4 Da
  • Sequence Length:18 aa
  • Isoelectric Point:12.21
  • Activity:Antibacterial
  • Sequence
        GNNRPVYIPQPRPPHPRL
  • Function:Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria. They seem to interfere with cell propagation.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000013    From 9 To 26 E-value: 0.00003 Score: 38.5
        GNNRPVYIPQPRPPHPRL
  • 2. L11A003026    From 11 To 28 E-value: 0.00003 Score: 38.5
        GNNRPVYIPQPRPPHPRL
  • 3. L01A000548    From 1 To 18 E-value: 0.00004 Score: 38.1
        GNNRPVYIPQPRPPHPRL
  • 4. L03A000012    From 9 To 26 E-value: 0.00005 Score: 37.7
        GNNRPVYIPQPRPPHPRI
  • 5. L01A000547    From 1 To 18 E-value: 0.00006 Score: 37.4
        GNNRPIYIPQPRPPHPRL

Structure

  •   Domains
  •   1  Name:Apidaecin    Interpro Link:IPR004828
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Agrobacterium tumefaciens  MIC:  0.2 μg/ml  (0.0948587 μM)  
  •   2  Target:  Erwinia salicis  MIC:  0.02 μg/ml  (0.00948587 μM)  
  •   3  Target:  Escherichia coli  MIC:  0.1 μg/ml  (0.0474293 μM)  
  •   4  Target:  Pseudomonas syringae  MIC:  0.1 μg/ml  (0.0474293 μM)  
  •   5  Target:  Rhizobium meliloti  MIC:  0.02 μg/ml  (0.00948587 μM)  
  •   6  Target:  Salmonella Newport  MIC:  0.2 μg/ml  (0.0948587 μM)  
  •   7  Target:  Salmonella typhimurium  MIC:  0.1 μg/ml  (0.0474293 μM)  
  •   8  Target:  Shigella flexneri  MIC:  0.1 μg/ml  (0.0474293 μM)  
  •   9  Target:  Corynebacterium insidiosum  MIC:  50 μg/ml  (23.7147 μM)  
  •   10  Target:  Bacillus megaterium  MIC:  100 μg/ml  (47.4293 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Tempst P.,Vaeck M.,Jacobs F.,Ampe C.,Casteels P.,
  •   Title:Apidaecins: antibacterial peptides from honeybees.
  •   Journal:EMBO J., 1989, 8, 2387-2391  [MEDLINE:90005446]
  •   [2]  Tempst P.,Casteels P.,Capaci T.,Casteels-Josson K.,
  •   Title:Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response.
  •   Journal:EMBO J., 1993, 12, 1569-1578  [MEDLINE:93223697]

Comments

  •   Comments

    •     No comments found on LAMP database



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