Record in detail


General Info

  • lamp_id:L01A000554
  • Name:LAN4_LACLL
  • FullName:Lantibiotic lacticin-481
  • Source:Lactococcus lactis subsp. lactis
  • Mass:2973.4 Da
  • Sequence Length:27 aa
  • Isoelectric Point:7.35
  • Activity:Antibacterial
  • Sequence
        KGGSGVIHTISHECNMNSWQFVFTCCS
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacticin 481 is a broad spectrum bacteriocin exhibiting activity against a wide range of lactic acid bacteria and C.tyrobutyricum.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A07804|    From 25 To 51 E-value: 0.000000000009 Score: 60.5
        KGGSGVIHTISHECNMNSWQFVFTCCS
  • 2. L01A000554    From 1 To 27 E-value: 0.00000000004 Score: 58.5
        KGGSGVIHTISHECNMNSWQFVFTCCS
  • 3. L12A08789|    From 23 To 48 E-value: 0.000000007 Score: 50.8
        GGNGVIKTISHECHMNTWQFIFTCCS
  • 4. L12A09160|    From 23 To 47 E-value: 0.000000008 Score: 50.8
        GGNGVLKTISHECNMNTWQFLFTCC
  • 5. L12A09475|    From 22 To 47 E-value: 0.000000008 Score: 50.8
        GGSGVIPTISHECHMNSFQFVFTCCS

Structure

  •   Domains
  •   1  Name:Lantibiotic_typ-A    Interpro Link:IPR007682
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Klaenhammer T.R.,Desmazeaud M.J.,Muriana P.M.,Piard J.-C.,
  •   Title:Purification and partial characterization of lacticin 481, a lanthionine-containing bacteriocin produced by Lactococcus lactis subsp. lactis CNRZ 481.
  •   Journal:Appl. Environ. Microbiol., 1992, 58, 279-284  [PubMed:16348628]
  •   [2]  de Vos W.M.,Desmazeaud M.J.,Rollema H.S.,Kuipers O.P.,Piard J.-C.,
  •   Title:Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis.
  •   Journal:J. Biol. Chem., 1993, 268, 16361-16368  [MEDLINE:93346379]
  •   [3]  Bourgeois C.M.,Thuault D.,le Pogam S.,Dufour A.,Rince A.,
  •   Title:Cloning, expression, and nucleotide sequence of genes involved in production of lactococcin DR, a bacteriocin from Lactococcus lactis subsp. lactis.
  •   Journal:Appl. Environ. Microbiol., 1994, 60, 1652-1657  [MEDLINE:94288641]
  •   [4]  Piard J.-C.,Haverkamp J.,Heerma W.,Lagerwerf F.M.,van den Hooven H.W.,
  •   Title:The structure of the lantibiotic lacticin 481 produced by Lactococcus lactis: location of the thioether bridges.
  •   Journal:FEBS Lett., 1996, 391, 317-322  [MEDLINE:96350545]

Comments

  •   Comments

    •     No comments found on LAMP database



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