Record in detail


General Info

  • lamp_id:L01A000564
  • Name:PA1C_RANPA
  • FullName:Palustrin-1c
  • Source:Rana palustris
  • Mass:2875.5 Da
  • Sequence Length:27 aa
  • Isoelectric Point:10.63
  • Activity:Antibacterial
  • Sequence
        ALSILRGLEKLAKMGIALTNCKATKKC
  • Function:Antimicrobial activity against Gram-negative bacterium E.coli. Possesses insulin-releasing activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000564    From 1 To 27 E-value: 0.000000002 Score: 53.1
        ALSILRGLEKLAKMGIALTNCKATKKC
  • 2. L01A000565    From 1 To 27 E-value: 0.000000005 Score: 51.6
        ALSILKGLEKLAKMGIALTNCKATKKC
  • 3. L01A000562    From 3 To 28 E-value: 0.0001 Score: 37.4
        FSILRGLKKLGKMGQAFVNCEIYKKC
  • 4. L01A000563    From 3 To 28 E-value: 0.0001 Score: 37
        FSILRGLKKLGNMGQAFVNCKIYKKC
  • 5. L11A004386    From 4 To 37 E-value: 0.24 Score: 26.2
        SIFRGVAKFASKGLGKKLAKLGVKLVACKISKQC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_2    Interpro Link:IPR012521
  •   2  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli  MIC:  80.51 μg/ml  (27.9986 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Conlon J.M.,Dulka J.,Knoop F.C.,Basir Y.J.,
  •   Title:Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris.
  •   Journal:Biochim. Biophys. Acta, 2000, 1543, 95-105  [PubMed:11087945]
  •   [2]  Shaw C.,McClean S.,Orr D.F.,Flatt P.R.,Marenah L.,
  •   Title:Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris.
  •   Journal:J. Endocrinol., 2004, 181, 347-354  [PubMed:15128283]
  •   [3]  Walker B.,Chen T.,Owens D.E.,Wang L.,Zhou M.,
  •   Title:Rapid identification of precursor cDNAs encoding five structural classes of antimicrobial peptides from pickerel frog (Rana palustris) skin secretion by single step "shotgun" cloning.
  •   Journal:Peptides, 2007, 28, 1605-1610  [PubMed:17698247]

Comments

  •   Comments

  •     No comments found on LAMP database



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