Record in detail

General Info

lamp_id:L01A000571
Name:HLP1_HYLPU
FullName:Hylaseptin-P1
Source:Hyla punctata
Mass:1311.6 Da
Sequence Length:14 aa
Isoelectric Point:9.53
Activity:Antibacterial, Antifungal
Sequence
GILDAIKAIAKAAG
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus, and the Gram-negative bacteria P.aeruginosa and E.coli. Has antifungal activity against C.albicans. No hemolytic activity has been detected.

Cross-Linking

Cross-linking
1 Database:APD 1249
2 Database:CAMP CAMPSQ533
3 Database:DBAASP 1163
4 Database:dbAMP dbAMP_03028
5 Database:DRAMP DRAMP01167
6 Database:SATPdb satpdb10815
7 Database:Uniprot P84292

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000571 From 1 To 14 E-value: 0.099 Score: 26.6
GILDAIKAIAKAAG
2. L13A028883 From 1 To 14 E-value: 0.5 Score: 24.3
GILDPIKAFAKAAG
3. L03A000120 From 42 To 55 E-value: 1.8 Score: 22.3
GILDTLKHLAKTAG
4. L13A015517 From 1 To 14 E-value: 2.1 Score: 21.9
GILDAIKAFANALG
5. L03A000121 From 42 To 55 E-value: 2.2 Score: 21.9
GILDTLKNLAKTAG

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: S. aureus ATCC 25923 MIC: 6.1 μg/ml (4.65081 μM)
2 Target: P. aeruginosa ATCC 27853 MIC: 48.8 μg/ml (37.2065 μM)
3 Target: E. coli ATCC 25922 MIC: 24.4 μg/ml (18.6032 μM)
4 Target: C. albicans wt MIC: 195.2 μg/ml (148.826 μM)
5 Target: C. albicans ATCC 1023 MIC: 256 μg/ml (195.181 μM)
6 Target: E. coli MIC: 32.003 μg/ml (24.4 μM)
7 Target: S. aureus MIC: 8.00076 μg/ml (6.1 μM)

Toxicity

Toxicity

Reference

Reference
[1] Silva L.P.,Leite J.R.S.A.,Regis W.C.B.,Sforca M.L.,Prates M.V.,
Title:The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.
Journal:J. Biol. Chem., 2004, 279, 13018-13026 [PubMed:14715660]

Comments

Comments