Record in detail


General Info

  • lamp_id:L01A000578
  • Name:PYRRH_PYRAP
  • FullName:Pyrrhocoricin
  • Source:Pyrrhocoris apterus
  • Mass:2340.6 Da
  • Sequence Length:20 aa
  • Isoelectric Point:10.65
  • Activity:Antibacterial
  • Sequence
        VDKGSYLPRPTPPRPIYNRN
  • Function:Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000578    From 1 To 20 E-value: 0.000002 Score: 42.4
        VDKGSYLPRPTPPRPIYNRN
  • 2. L11A013561    From 1 To 20 E-value: 0.000004 Score: 41.6
        VDKGSYLPRPTPPKPIYNRN
  • 3. L11A013559    From 1 To 20 E-value: 0.00001 Score: 40
        VDKGSYKPRPTPPRPIYNRN
  • 4. L11A013549    From 1 To 20 E-value: 0.00002 Score: 39.3
        VDKGSYKPRPTPPKPIYNRN
  • 5. L11A013550    From 1 To 20 E-value: 0.00002 Score: 38.9
        VDKGSYRPRPTPPKPIYNRN

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures
  •   1
    PDB:3DPO
    Method:X-ray
    Chains:C/D=7-11
  •   2
    PDB:3DPP
    Method:X-ray
    Chains:C/D=7-20
  •   3
    PDB:3DPQ
    Method:X-ray
    Chains:C/D/G/H=7-20
  •   4
    PDB:3DPO
    Method:X-ray
    Chains:C/D=7-11
  •   5
    PDB:3DPP
    Method:X-ray
    Chains:C/D=7-20
  •   6
    PDB:3DPQ
    Method:X-ray
    Chains:C/D/G/H=7-20

Activity

  •   Antibacterial Activities
  •   1  Target:  M.luteus  MIC:  80 μg/ml  (34.1793 μM)  
  •   2  Target:  B.megaterium  MIC:  80 μg/ml  (34.1793 μM)  
  •   3  Target:  E.coliD22  MIC:  0.3 μg/ml  (0.128172 μM)  
  •   4  Target:  A.tumefaciens  MIC:  3 μg/ml  (1.28172 μM)  
  •   5  Target:  S.typhimurium  MIC:  10 μg/ml  (4.27241 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Holder F.,Lanot R.,Hegy G.,Dupont A.,Cociancich S.,
  •   Title:Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.
  •   Journal:Biochem. J., 1994, 300, 567-575  [MEDLINE:94271176]
  •   [2]  Holder F.,Lanot R.,Hegy G.,Dupont A.,Cociancich S.,
  •   Title:Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.
  •   Journal:Biochem. J., 1994, 300, 567-575  [MEDLINE:94271176]
  •   [3]  Otvoes L. Jr.,Urge L.,Bulet P.,Hoffmann R.,
  •   Title:Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects.
  •   Journal:Biochim. Biophys. Acta, 1999, 1426, 459-467  [MEDLINE:99177428]
  •   [4]  Otvoes L. Jr.,Urge L.,Bulet P.,Hoffmann R.,
  •   Title:Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects.
  •   Journal:Biochim. Biophys. Acta, 1999, 1426, 459-467  [MEDLINE:99177428]

Comments

  •   Comments

    •     No comments found on LAMP database



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