Record in detail


General Info

  • lamp_id:L01A000587
  • Name:XT7_XENTR
  • FullName:Antimicrobial peptide 7
  • Source:Xenopus tropicalis
  • Mass:1777.2 Da
  • Sequence Length:18 aa
  • Isoelectric Point:10.8
  • Activity:Antibacterial, Antifungal,Anticancer
  • Sequence
        GLLGPLLKIAAKVGSNLL
  • Function:Has very strong antibacterial activity against many Gram-negative bacteria and the Gram-positive bacteria S.pneumoniae and Enterococcus sp. There is moderate antimicrobial activity against the Gram-negative bacterium P.aeruginosa and yeast C.albicans and weaker activity against the Streptococcal strains and E.coli. Has hemolytic activity against human red blood cells. Seems to disrupt the membranes by adopting an alpha-helical conformation.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000587    From 1 To 18 E-value: 0.0006 Score: 34.3
        GLLGPLLKIAAKVGSNLL
  • 2. L13A019981    From 1 To 17 E-value: 0.001 Score: 33.1
        GLLGPLLKIAAKVGSNL
  • 3. L13A023115    From 1 To 18 E-value: 0.002 Score: 32.3
        GLLGPLLKIAAKVGKNLL
  • 4. L13A020342    From 2 To 18 E-value: 0.002 Score: 32.3
        LLGPLLKIAAKVGSNLL
  • 5. L13A010622    From 1 To 18 E-value: 0.002 Score: 32.3
        GLLGPLLKIAKKVGSNLL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  44.43 μg/ml  (25 μM)  
  •   2  Target:  S. aureus  MIC:  10.6632 μg/ml  (6 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Conlon J.M.,Knoop F.C.,Soto A.,Ali M.F.,
  •   Title:Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).
  •   Journal:Biochim. Biophys. Acta, 2001, 1550, 81-89  [PubMed:11738090]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: