Record in detail

General Info

lamp_id:L01A000590
Name:XT4_XENTR
FullName:Antimicrobial peptide 4
Source:Xenopus tropicalis
Mass:2318.8 Da
Sequence Length:22 aa
Isoelectric Point:10.8
Activity:Antibacterial, Antifungal
Sequence
GVFLDALKKFAKGGMNAVLNPK
Function:Has very strong antimicrobial activity against Gram-positive bacterium S.aureus and yeast C.albicans, and very weak activity against Gram-negative bacterium E.coli. Has strong hemolytic activity against human red blood cells.

Cross-Linking

Cross-linking
1 Database:APD 426
2 Database:CAMP CAMPSQ550
3 Database:DBAASP 3156
4 Database:dbAMP dbAMP_04213
5 Database:DRAMP DRAMP02133
6 Database:SATPdb satpdb11365
7 Database:Uniprot P84384
8 Database:AMD XT4_XENTR

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000590 From 1 To 22 E-value: 0.0000004 Score: 45.1
GVFLDALKKFAKGGMNAVLNPK
2. L13A022477 From 1 To 22 E-value: 0.00005 Score: 38.1
GLFLDTLKKFAKAGMEAVINPK
3. L11A002287 From 1 To 22 E-value: 0.00008 Score: 37.4
GLFLDTLKKFAKAGMEAVTNPK
4. L13A017793 From 10 To 25 E-value: 0.005 Score: 31.2
LKQFAKGGVNAVLNPK
5. L13A010425 From 5 To 25 E-value: 0.006 Score: 31.2
TILGGLKKFAKGGLDAIVNPK

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 41.7384 μg/ml (18 μM)
2 Target: S. aureus MIC: 231.88 μg/ml (100 μM)

Toxicity

Toxicity

Reference

Reference
[1] Conlon J.M.,Knoop F.C.,Soto A.,Ali M.F.,
Title:Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).
Journal:Biochim. Biophys. Acta, 2001, 1550, 81-89 [PubMed:11738090]

Comments

Comments