Record in detail


General Info

  • lamp_id:L01A000593
  • Name:XT1_XENTR
  • FullName:Antimicrobial peptide 1
  • Source:Xenopus tropicalis
  • Mass:2852.5 Da
  • Sequence Length:27 aa
  • Isoelectric Point:11.93
  • Activity:Antibacterial, Antifungal
  • Sequence
        GFLGPLLKLAAKGVAKVIPHLIPSRQQ
  • Function:Has very weak antimicrobial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli and stronger activity against yeast C.albicans. Enhances the antibacterial activity of XT3. Has hemolytic activity against human red blood cells.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000593    From 1 To 27 E-value: 0.0000000008 Score: 54.3
        GFLGPLLKLAAKGVAKVIPHLIPSRQQ
  • 2. L13A014632    From 3 To 27 E-value: 0.0003 Score: 35.8
        FGTFAKMALKGASKLIPHLLPSRQQ
  • 3. L13A012176    From 1 To 27 E-value: 0.0003 Score: 35.4
        GVFGLLAKAALKGASKLIPHLLPSRQQ
  • 4. L13A016038    From 14 To 27 E-value: 0.009 Score: 30.8
        VAKVIPHLIPSRQQ
  • 5. L11A008338    From 2 To 17 E-value: 0.013 Score: 30
        KGASKLIPHLLPSRQQ

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  17.115 μg/ml  (6 μM)  
  •   2  Target:  S. aureus  MIC:  14.2625 μg/ml  (5 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Conlon J.M.,Knoop F.C.,Soto A.,Ali M.F.,
  •   Title:Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).
  •   Journal:Biochim. Biophys. Acta, 2001, 1550, 81-89  [PubMed:11738090]

Comments

  •   Comments

    •     No comments found on LAMP database



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