Record in detail


General Info

  • lamp_id:L01A000598
  • Name:PROTO_AGEPP
  • FullName:Protonectin
  • Source:Agelaia pallipes pallipes
  • Mass:1210.5 Da
  • Sequence Length:12 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial
  • Sequence
        ILGTILGLLKGL
  • Function:Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells. Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria. Shows no hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000598    From 1 To 12 E-value: 1.6 Score: 22.3
        ILGTILGLLKGL
  • 2. L13A021437    From 1 To 11 E-value: 3.4 Score: 21.2
        ILGTILGLLKG
  • 3. L01A000028    From 1 To 12 E-value: 4.9 Score: 20.8
        ILGTILGLLKSL
  • 4. L11A007104    From 1 To 12 E-value: 5.6 Score: 20.4
        ILGTILGPLKGL
  • 5. L11A007103    From 1 To 12 E-value: 5.6 Score: 20.4
        ILGTIPGLLKGL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  25 μg/ml  (20.6526 μM)  
  •   2  Target:  P.aeruginosa  MIC:  1.7 μg/ml  (1.40438 μM)  
  •   3  Target:  B. subtilis  MIC:  3.1 μg/ml  (2.56093 μM)  
  •   4  Target:  S.aureus  MIC:  12.5 μg/ml  (10.3263 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Palma M.S.,Marques M.R.,de Souza B.M.,Mendes M.A.,
  •   Title:Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.
  •   Journal:Toxicon, 2004, 44, 67-74  [PubMed:15225564]
  •   [2]  Palma M.S.,Delazari dos Santos L.,Monson de Souza B.,Mendes M.A.,
  •   Title:Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
  •   Journal:Rapid Commun. Mass Spectrom., 2004, 18, 636-642  [PubMed:15052574]

Comments

  •   Comments

    •     No comments found on LAMP database



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