Record in detail


General Info

  • lamp_id:L01A000613
  • Name:KAS1_KASSE
  • FullName:Kassinatuerin-1
  • Source:Kassina senegalensis
  • Mass:2283.8 Da
  • Sequence Length:21 aa
  • Isoelectric Point:9.26
  • Activity:Antibacterial, Antifungal
  • Sequence
        GFMKYIGPLIPHAVKAISDLI
  • Function:Shows broad-spectrum antimicrobial activity against the Gram-negative bacterium E.coli (MIC=6.25 uM), K.pneumoniae (MIC=25 uM), E.cloacae (MIC=6.25 uM), P.aeruginosa (MIC=25 uM), the Gram-positive bacterium S.aureus (MIC=6.25 uM), S.epidermidis (MIC=6.25 uM), E.faecalis (MIC=12.5 uM), and the fungus C.albicans (MIC=100 uM). Has no antimicrobial effect against P.mirabilis (MIC>100 uM). Has relatively high cytolytic and hemolytic activities. Its alpha-helix has considerable amphipathic character.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000613    From 1 To 21 E-value: 0.0000005 Score: 44.7
        GFMKYIGPLIPHAVKAISDLI
  • 2. L13A013894    From 1 To 21 E-value: 0.000002 Score: 42.7
        GFMKYIGPLIPHKVKAISDLI
  • 3. L13A015623    From 1 To 21 E-value: 0.000003 Score: 42
        GFMKYIGPLIPHAVKAISKLI
  • 4. L13A014992    From 1 To 21 E-value: 0.000003 Score: 42
        GFMKYIGPLIPHAVKAISKLI
  • 5. L13A021073    From 1 To 21 E-value: 0.000009 Score: 40.4
        GFMKYIGPLIPHAVKAIKKLI

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  14.2738 μg/ml  (6.25 μM)  
  •   2  Target:  S. aureus  MIC:  14.2738 μg/ml  (6.25 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Conlon J.M.,Knoop F.C.,Mattute B.,
  •   Title:Kassinatuerin-1: a peptide with broad-spectrum antimicrobial activity isolated from the skin of the hyperoliid frog, Kassina senegalensis.
  •   Journal:Biochem. Biophys. Res. Commun., 2000, 268, 433-436  [MEDLINE:20145451]
  •   [2]  Sonnevend A.,Knoop F.C.,Galadari S.,Abraham B.,Conlon J.M.,
  •   Title:Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives.
  •   Journal:Peptides, 2005, 26, 2104-2110  [PubMed:15885852]

Comments

  •   Comments

    •     No comments found on LAMP database



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