Record in detail


General Info

  • lamp_id:L01A000615
  • Name:NIGR2_PELNI
  • FullName:Nigrocin-2
  • Source:Pelophylax nigromaculatus
  • Mass:2030.6 Da
  • Sequence Length:21 aa
  • Isoelectric Point:9.67
  • Activity:Antibacterial, Antifungal
  • Sequence
        GLLSKVLGVGKKVLCGVSGLC
  • Function:Thanks to its single linear amphipathic alpha-helix, may integrate into membrane phospholipids, leading to lysis of the membrane. Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C.albicans. Has no hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000615    From 1 To 21 E-value: 0.00004 Score: 38.5
        GLLSKVLGVGKKVLCGVSGLC
  • 2. L13A025391    From 1 To 21 E-value: 0.00005 Score: 38.1
        GLLSKILGVGKKVLCGVSGLC
  • 3. L13A019060    From 1 To 21 E-value: 0.0001 Score: 36.6
        GLLSKILGVGKKVLCGLSGMC
  • 4. L13A028336    From 1 To 21 E-value: 0.0002 Score: 35.8
        GIFSKVLGAGKKVLCGVSGLC
  • 5. L03A000046    From 1 To 20 E-value: 0.0002 Score: 35.8
        GLLSKVLGVGKKVLCGVSGL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  10.153 μg/ml  (5 μM)  
  •   2  Target:  S. aureus  MIC:  30.459 μg/ml  (15 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kim S.S.,Kim S.,Ahn H.-C.,Park S.-H.,Park S.,
  •   Title:Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
  •   Journal:FEBS Lett., 2001, 507, 95-100  [MEDLINE:21538640]

Comments

  •   Comments

    •     No comments found on LAMP database



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